Observation

Generalized Epidermal Nevus and Acanthosis Nigricans Due to a Postzygotic Variant

JAMA Dermatology 10.1001/jamadermatol.2025.4539

December 03, 2025 at 11:00 AM EST

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This case report describes a patient with a postzygotic variant leading to severe achondroplasia with developmental delay and acanthosis nigricans accompanied by both acanthosis nigricans and generalized epidermal nevus.

Corresponding Author: Zhimiao Lin, MD, Dermatology Hospital, Southern Medical University, No. 2 Lujing Rd, Yuexiu District, Guangzhou 510091, China (zhimiaolin@bjmu.edu.cn).

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