Cross-Modal Imaging in Noninvasive Identification of Histologic Features of Skin

Can cross-modal noninvasive imaging obtain in vivo images that align with skin histopathology, and can blinded readers accurately identify tissue features on these images?In this diagnostic study, 65 participants undergoing skin biopsy were imaged with a novel cross-modal system. Expert readers used traditional hematoxylin and eosin histopathology to validate skin features identified on cross-modal imaging and to train blinded physician readers; in performance testing, blinded readers scored 96.4% accuracy in feature identification.The results of this trial provide evidence that physicians may use cross-modal imaging in the noninvasive identification of histologic features of skin.

Corresponding Author: Michael Z. Wang, MD, Golden State Dermatology, 2255 Ygnacio Valley Rd, Suite B-1, Walnut Creek, CA 94598 (mwang@gsdermca.com).

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