Observation

Postzygotic Gain-of-Function Variant in and Inflammatory Linear Verrucous Epidermal Nevus

JAMA Dermatology 10.1001/jamadermatol.2025.2205

July 23, 2025 at 11:00 AM EDT

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This case report describes a young woman with diffuse pruritic erythematous plaques and papules since birth who presented with coalesced spiked keratotic papules on the palms and chalky white fingernails.

Corresponding Author: Zhimiao Lin, MD, Dermatology Hospital, Southern Medical University, Lujing St, Guangzhou 510091, China (zhimiaolin@bjmu.edu.cn).

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