Non-HDL Cholesterol and Apolipoprotein B Measures and Risk of Atherosclerotic Cardiovascular Disease

Does non–high-density lipoprotein (non-HDL) cholesterol provide information on atherosclerotic cardiovascular disease (ASCVD) beyond apolipoprotein B (apoB), and vice versa?This cohort study included 94 398 individuals not taking lipid-lowering medication at baseline. Discordant high non-HDL cholesterol levels greater than the median with apoB values less than median values were associated with increased risk of myocardial infarction and ASCVD as were discordant high apoB values greater than the median with non-HDL cholesterol levels less than median values.Results of this study suggest that, in individuals not taking lipid-lowering medication, non-HDL cholesterol and apoB provide clinically important information on risk of ASCVD that cannot be achieved by assessing either one of them alone, indicating that both cholesterol content and particle number are important for risk.

Corresponding Author: Martin Bødtker Mortensen, MD, PhD, Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark (martin.bodtker.mortensen@clin.au.dk).

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