Original Investigation

Social Determinants of Health and Clinical Outcomes in Hypertrophic Cardiomyopathy

JAMA Cardiology 10.1001/jamacardio.2025.4869

January 07, 2026 at 11:00 AM EST

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Are area-based social determinants of health (SDOH) associated with cardiovascular outcomes in patients with hypertrophic cardiomyopathy (HCM)?In this cohort study that included 4431 adult patients with HCM, residing in an area with either lower median household income or worse social deprivation index was significantly associated with adverse cardiovascular outcomes (heart failure, ventricular and atrial arrhythmias, stroke, and death).Area-based SDOH may be useful for risk assessment in patients with HCM and may inform strategies to reduce health disparities and improve outcomes.

Corresponding Authors: Sharlene Day, MD, Division of Cardiovascular Medicine, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104 (sharlene.day@pennmedicine.upenn.edu); Sadiya S. Khan, MD, MSc, Departments of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, 14-002, Chicago, IL 60611 (s-khan-1@northwestern.edu).

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