Low-Density Lipoprotein Cholesterol Levels and Neoatherosclerosis After STEMI

Does achieving guideline-recommended low-density lipoprotein cholesterol (LDL-C) levels help prevent neoatherosclerosis after drug-eluting stent implantation in patients with ST-segment elevation myocardial infarction (STEMI)?In this secondary analysis of the CONNECT randomized clinical trial, neoatherosclerosis was less frequent in patients who achieved guideline-endorsed LDL-C levels and received high-intensity statin therapy. On-treatment LDL-C level emerged as an independent determinant of neoatherosclerosis.Achieving guideline-recommended LDL-C levels through intensive lipid-lowering therapy may help prevent neoatherosclerosis formation and prevent late stent failure in patients with STEMI.

Corresponding Author: Lorenz Räber, MD, PhD, Department of Cardiology, Bern University Hospital, Inselspital, Anna-Seiler-Haus, Freiburgstrasse 20, 3010 Bern, Switzerland (lorenz.raeber@insel.ch).

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