Clonal Hematopoiesis and Incident Heart Failure

Are specific clonal hematopoiesis of indeterminate potential (CHIP) driver gene subtypes associated with incident heart failure, and do CHIP-associated comorbidities mediate this association?In this cohort study of 417 616 UK Biobank participants, was weakly associated with incident heart failure, whereas non- was more strongly associated with incident heart failure.Study results suggest that CHIP, especially non- CHIP, was an independent risk factor for the development of heart failure and may be a novel target for heart failure prevention and treatment.

Corresponding Author: Michael C. Honigberg, MD, MPP, Cardiology Division, Massachusetts General Hospital, 185 Cambridge St, CPZN 3.190, Boston, MA 02114 (mhonigberg@mgh.harvard.edu).

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