Original Investigation

Mechanisms Underlying Alterations in Cardiac Conduction After Transcatheter Aortic Valve Replacement

JAMA Cardiology 10.1001/jamacardio.2025.4442

December 10, 2025 at 11:00 AM EST

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What are the site(s) of heart block in patients undergoing transcatheter aortic valve replacement (TAVR), and what are markers of risk for heart block?In this cohort study of 409 patients undergoing TAVR, His bundle studies identified block in both the atrioventricular (AV) node and His bundle and were predictive of delayed block. These observations suggest mechanisms underlying intraprocedural block differ from those causing postprocedural block.Differing prediction models are necessary to identify patients at risk for heart block occurring during vs following TAVR implants.

Corresponding Author: Alfred E. Buxton, MD, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Baker 4, Boston, MA 02215 (abuxton@bidmc.harvard.edu).

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