Editorial

Carotid Artery Stenosis—An Impactful Bias in Ischemic Stroke Classification

JAMA Cardiology 10.1001/jamacardio.2025.4206

November 12, 2025 at 11:00 AM EST

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This Viewpoint argues that risk classification in ischemic stroke should be expanded beyond stenosis severity to encompass other complementary features, such as plaque morphology, composition, and inflammation.

Corresponding Author: Peter Libby, MD, Heart and Vascular Institute, Center of Excellence in Vascular Biology, and Center for Inflammation Imaging at Mass General Brigham Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115 (plibby@bwh.harvard.edu).

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