Original Investigation

Aggressive Risk Factor Reduction Study for Atrial Fibrillation Implications for Ablation Outcomes

JAMA Cardiology 10.1001/jamacardio.2025.4007

October 29, 2025 at 11:00 AM EDT

Read the full article

Among patients with atrial fibrillation undergoing catheter ablation, does lifestyle and risk factor management improve 12-month freedom from arrhythmia recurrence?In this randomized clinical trial, among 122 patients with symptomatic atrial fibrillation undergoing de novo catheter ablation, lifestyle and risk factor management improved the primary end point of arrhythmia freedom at 12 months after ablation when compared with usual care.This finding demonstrates the need for comprehensive risk factor management to reduce arrhythmia recurrence after catheter ablation.

Corresponding Author: Prashanthan Sanders, MBBS, PhD, Centre for Heart Rhythm Disorders, Department of Cardiology, Royal Adelaide Hospital, 1 Port Rd, Adelaide 5000, Australia (prash.sanders@adelaide.edu.au).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2025.4007?utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_term=102925

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.

Editor's Picks