Contributions of Common, Rare, and Somatic Genetic Variants to Incidence of Atrial Fibrillation

What are the contributions of common, rare, and somatic variations, and their association with the incidence of atrial fibrillation (AF)?This cohort study including 416 085 individuals demonstrated the individual and complementary roles of common, rare, and somatic variations for AF onset. The rare variants, polygenic score, and clonal hematopoiesis of indeterminate potential enhanced the prediction of incident AF when added to clinical factors.Results suggest that leveraging comprehensive genetic information may aid in AF prevention and risk stratification.

Corresponding Authors: Akl C. Fahed, MD, MPH, Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114 (afahed@mgh.harvard.edu); Minxian Wang, PhD, National Genomics Data Center, China National Center for Bioinformation, No. 1 Beichen West Road, Chaoyang District, Beijing 100101, China (wangmx@cncb.ac.cn).

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