Brief Report

Cumulative Cardiovascular Health Score Through Young Adulthood and Cardiovascular and Kidney Outcomes in Midlife

JAMA Cardiology 10.1001/jamacardio.2025.3269

October 01, 2025 at 11:00 AM EDT

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Is a higher cumulative cardiovascular health (CVH) score during young adulthood associated with a lower risk of cardiovascular and kidney events in midlife?In this cohort study of 241 924 adults in Korea, a 100-point × year higher cumulative CVH (Life’s Essential 8) score from 30 to 40 years of age was associated with lower hazard of midlife cardiovascular and kidney events by 34% and 35%, respectively.The findings suggest that a high cumulative CVH score (points × years) can serve as a useful target for primordial prevention, with earlier achievement and longer maintenance of a high CVH score associated with lower risks of premature cardiovascular and kidney events.

Corresponding Author: Hokyou Lee, MD, PhD, Department of Preventive Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea (hokyou.lee@yuhs.ac).

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