Brief Report

First-in-Human Real-Time MR-Guided Ventricular Ablation for Idiopathic Outflow Tract Premature Ventricular Complexes

JAMA Cardiology 10.1001/jamacardio.2025.3000

September 17, 2025 at 11:00 AM EDT

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Can real-time magnetic resonance (MR)–guided radiofrequency ablation be safely and effectively performed for ventricular arrhythmias without fluoroscopy?In this first-in-human case from the VISABL-VT trial, a 73-year-old man underwent successful MR-guided ablation for symptomatic premature ventricular complexes using an MR-compatible electrophysiology platform, with complete ectopy suppression and no complications during or after the procedure.This case demonstrates the technical feasibility and safety of entirely real-time MR-guided ventricular ablation, supporting further clinical investigation.

Corresponding Author: Marco J. W. Götte, MD, PhD, Department of Cardiology, Amsterdam University Medical Centers, De Boelelaan 1117, 1082HV Amsterdam, the Netherlands (mjw.gotte@amsterdamumc.nl).

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