Lung Transplant for Refractory Lung-Limited Stage IV Non–Small Cell Lung Cancer

Among selected adults with medically refractory, lung-limited, stage IV non–small cell lung cancer (NSCLC), what are the outcomes with lung transplant and how does early overall survival compare with medical management alone?In this prospective study including adults, 17 of 98 patients with stage IV NSCLC underwent lung transplant. All patients who underwent lung transplant exhibited respiratory failure (306 without cancer underwent lung transplant for end-stage pulmonary disease); overall survival was higher in the 17 adults who underwent lung transplant than in the 81 patients who received medical management alone.Among selected patients with stage IV NSCLC, lung transplant was associated with longer early overall survival than medical management alone.

Corresponding Authors: Ankit Bharat, MD (ankit.bharat@nm.org), and Young Kwang Chae, MD (ychae@nm.org), Canning Thoracic Institute, Feinberg School of Medicine, Northwestern University, 676 N Saint Clair St, Chicago, IL 60611.

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