Review

Hepatitis B

JAMA 10.1001/jama.2026.6070

May 04, 2026 at 11:05 AM EDT

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HBV infection causes approximately 1.1 million deaths annually worldwide. Universal HBV vaccination, particularly birth-dose administration, is the most effective strategy to prevent HBV infection. Among patients with HBV infection, antiviral therapy decreases progression to cirrhosis and liver failure and reduces the risk of HCC.

Corresponding Author: Anna S. Lok, MD, Division of Gastroenterology and Hepatology, University of Michigan, 1500 E Medical Center Dr, 3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109 (aslok@med.umich.edu).

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