Symptom-Based Dosing for Neonatal Opioid Withdrawal

Does pharmacologic treatment with a symptom-based dosing approach decrease time to medical readiness for discharge compared with a scheduled opioid taper for infants with opioid withdrawal cared for with the Eat, Sleep, Console approach?In this cluster, crossover randomized clinical trial including 383 infants cared for with the Eat, Sleep, Console approach, time to medical readiness for discharge was 2.3 days shorter for infants treated with symptom-based dosing compared with a scheduled opioid taper. No difference was noted in safety outcomes through 3 months of age.Symptom-based dosing decreased time to medical readiness for discharge for infants with opioid withdrawal cared for with the Eat, Sleep, Console approach.

Corresponding Author: Lori A. Devlin, DO, Department of Pediatrics, University of Louisville School of Medicine, 571 S Floyd St, Ste 342, Louisville, KY 40202 (lori.devlinphinney@louisville.edu).

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