Original Investigation

Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients

JAMA 10.1001/jama.2026.2897

March 17, 2026 at 4:35 AM EDT

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Does a restrictive (low-use) wrist-strap physical restraint strategy, compared with a liberal (high-use) strategy, reduce coma or delirium in adult patients receiving mechanical ventilation in the intensive care unit?In this randomized clinical trial of 405 adults receiving invasive mechanical ventilation, the number of days alive without coma or delirium during the first 14 days after randomization did not differ between the low- and high-use restraint strategies (6.67 vs 6.30 days). Delirium; self-extubation; day-90 mortality; and 90-day functional, cognitive, and psychological outcomes were similar between groups.In adult patients receiving mechanical ventilation in the intensive care unit, a low-use wrist-strap physical restraint strategy did not improve coma- or delirium-free days.

Corresponding Author: Romain Sonneville, MD, PhD, Service de Médecine Intensive et Réanimation Hôpital Bichat – Claude-Bernard, 46 rue Henri Huchard, 75877 Paris Cedex, France (romain.sonneville@aphp.fr).

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