Review

Endometrial Cancer

JAMA 10.1001/jama.2026.2248

April 13, 2026 at 11:00 AM EDT

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Endometrial cancer accounts for 95% of uterine cancers, which are the fourth most common cancer in women in the US. Surgery is first-line treatment. Adjuvant radiation is recommended for early-stage, high-intermediate risk endometrial cancer. Adjuvant chemotherapy with carboplatin and paclitaxel is recommended for early-stage disease with aggressive histologic subtypes and advanced-stage disease, which is also treated with immunotherapy in some cases.

Corresponding Author: Karen McLean, MD, PhD, Roswell Park Comprehensive Cancer Center, Elm and Carlton St, Buffalo, NY 14203 (Karen.McLean@RoswellPark.org).

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