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Editor's Pick Perspective

The Orexin System—A Key Component of Sleep Regulatory Networks and Involvement in Narcolepsy

JAMA 10.1001/jama.2026.15598

September 09, 2026 at 8:00 AM EDT

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In this Perspective, 2026 Albert Lasker Basic Medical Research Award winners Emmanuel Mignot, MD, PhD, and Masashi Yanagisawa, MD, PhD, discuss their identification of the brain peptide orexin and how it relates to sleep, specifically orexin deficiency and narcolepsy.

Corresponding Author: Emmanuel Mignot, MD, PhD, Stanford University, 1050 Arastradero Rd, Building A, Palo Alto, CA 94304 (mignot@stanford.edu).

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