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Editor's Pick Original Investigation

Cold and Room-Temperature Platelets in Cardiac Surgery

JAMA 10.1001/jama.2026.13328

August 17, 2026 at 11:00 AM EDT

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For patients undergoing cardiac surgery, CSPs stored up to 21 days are noninferior to RTPs for the control of active surgical bleeding. Use of CSPs may allow for increased availability of platelets by reducing wastage and shortages and may allow for incorporation of platelets into inventory at locations where platelets cannot be maintained due to the 5- to 7-day shelf life of RTPs.

This Original Investigation has an accompanying commentary.

Corresponding Author: Philip C. Spinella, MD, University of Pittsburgh, 3250 Fifth Ave, Ste 500, Pittsburgh, PA 15213 (spinella@pitt.edu).

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