JAMA Guide to Statistics and Methods

Estimating Intervention Effects With Difference-in-Differences

JAMA 10.1001/jama.2026.12551

July 16, 2026 at 11:00 AM EDT

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This Guide to Statistics and Methods provides an overview of the difference-in-differences method, a tool for addressing potential biases by contrasting the change in the outcome of interest from before an intervention to after, between settings experiencing and those not experiencing the intervention.

Corresponding Author: Alyssa Bilinski, PhD, Brown University School of Public Health, 121 S Main St, 8th Floor, Providence, RI 02903 (alyssa_bilinski@brown.edu).

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