JAMA Guide to Statistics and Methods

The Hochberg Procedure for the Comparison of Multiple End Points

JAMA 10.1001/jama.2026.0191

March 05, 2026 at 11:00 AM EST

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This Guide to Statistics and Methods provides an overview of the Hochberg procedure, an effective tool for avoiding false-positive conclusions in clinical trials reporting multiple end points.

Corresponding Author: Jessica R. Overbey, DrPH, Berry Consultants, LLC, 3345 Bee Caves Rd, Ste 201, Austin, TX 78746 (jessica@berryconsultants.net).

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