Original Investigation

Coffee and Tea Intake, Dementia Risk, and Cognitive Function

JAMA 10.1001/jama.2025.27259

February 09, 2026 at 11:00 AM EST

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Is long-term intake of caffeinated and decaffeinated coffee associated with risk of dementia and cognitive outcomes?In this prospective cohort study of 131 821 individuals from 2 cohorts with up to 43 years of follow-up, 11 033 dementia cases were documented. Higher caffeinated coffee intake was significantly associated with lower risk of dementia. Decaffeinated coffee intake was not significantly associated with dementia risk.Higher caffeinated coffee intake was associated with more favorable cognitive outcomes.

Corresponding Author: Dong D. Wang, MD, ScD, Brigham and Women’s Hospital, 181 Longwood Ave, Boston, MA 02115 (dow471@mail.harvard.edu).

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