Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults

For acute sinusitis in adults younger than 65 years, is standard-dose amoxicillin-clavulanate associated with different risks of treatment failure and adverse events compared with standard-dose amoxicillin?In this retrospective cohort study of 521 244 adults with acute sinusitis, overall treatment failure was rare (3.1%). There was no observed difference in treatment failure between treatment groups and an elevated relative risk, corresponding to a small absolute increase in risk, of yeast infections and infections among patients treated with amoxicillin-clavulanate.These findings support standard-dose amoxicillin as a preferred empiric choice for adults younger than 65 years with uncomplicated acute sinusitis for whom an antibiotic is indicated.

Corresponding Author: Timothy J. Savage, MD, MPH, MSc, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, 1620 Tremont St, Ste 3030, Boston, MA 02120 (tsavage@mgb.org).

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