JAMA Guide to Statistics and Methods

Win Ratio Method for Hierarchical Composite Outcomes in Randomized Clinical Trials

JAMA 10.1001/jama.2025.25686

January 28, 2026 at 11:00 AM EST

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This Guide to Statistics and Methods provides an overview of the win ratio method for analyzing composite end points in randomized clinical trials, including its benefits and limitations.

Corresponding Author: John M. Cunningham, MD, Long School of Medicine, University of Texas Health at San Antonio, 7703 Floyd Curl Dr, Mail Code 7982, San Antonio, TX 78229-3900 (cunninghamj1@uthscsa.edu).

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