Risk-Based vs Annual Breast Cancer Screening

Is risk-based breast cancer screening as safe, less morbid, and as acceptable to women as annual screening?Risk-based breast cancer screening, where screening intensity and risk-reduction counseling are tailored to individual risk, was noninferior to annual screening (rate difference, −18.0 per 100 000 person-years). Importantly, women in the highest risk category, assigned to screen every 6 months, had no stage ≥IIB cancers; no overall reduction in biopsies was observed, but the rates for cancer detection, biopsy, and mammograms increased with rising risk in the risk-based group.Risk-based breast cancer screening is safe and acceptable, offering an opportunity to modernize screening in the precision medicine era.

Corresponding Author: Laura J. Esserman, MD, MBA, University of California, San Francisco, Precision Cancer Medicine Building, 1825 4th St, 3rd Floor, San Francisco, CA 94158 (laura.esserman@ucsf.edu).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.