Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults

Among critically ill adults receiving invasive mechanical ventilation, does early use of an automated closed-loop ventilation system increase ventilator-free days at day 28 compared with protocolized conventional ventilation?In this international randomized clinical trial including 1201 critically ill adults, the median number of ventilator-free days at day 28 was 16.7 in the closed-loop ventilation group and 16.3 in the conventional ventilation group, a difference that was not statistically significant.Early initiation of automated closed-loop ventilation did not increase ventilator-free days at day 28 compared with protocolized conventional ventilation.

Corresponding Author: Jante S. Sinnige, MD, Department of Intensive Care, Amsterdam University Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands (j.s.sinnige@amsterdamumc.nl).

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