Prenatal Exposure to Acid-Suppressive Medications and Risk of Neuropsychiatric Disorders in Children

Is prenatal acid-suppressive medication exposure associated with neuropsychiatric disorders in offspring?In this cohort study of more than 2.7 million mother-child pairs, models without sibling controls identified modestly increased risks of neuropsychiatric disorders in children associated with acid-suppressive medication use during pregnancy (adjusted hazard ratio [HR], 1.13). However, sibling-matched analyses did not identify evidence of increased risk of any disorder (adjusted HR, 1.0), including attention-deficit/hyperactivity disorder, autism spectrum disorders, intellectual disability, severe neuropsychiatric disorder, and obsessive-compulsive disorder.Prenatal exposure to acid-suppressive medication was not associated with children’s risk of neuropsychiatric disorders in sibling-control analyses; associations observed in other models may reflect unmeasured confounding.

Corresponding Authors: Dong Keon Yon, MD, PhD, Department of Pediatrics, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea (yonkkang@gmail.com); Hayeon Lee, PhD, Department of Biomedical Engineering, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin 17104, South Korea (wwhy28@khu.ac.kr).

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