Original Investigation

A Lay Health Worker–Led Symptom Intervention and Acute Care Use in Older Adults With Cancer

JAMA 10.1001/jama.2025.23403

December 30, 2025 at 11:00 AM EST

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Does a lay health worker–led symptom assessment intervention reduce acute care use among older adults with cancer at scale?In this randomized clinical trial of 416 participants, those who received the lay health worker symptom assessment intervention had significant reductions in any emergency department use (61 [30.5%] vs 103 [47.7%]) and any hospitalization (37 [18.5%] vs 86 [39.8%]) at 12 months compared with those who received usual cancer care only.These findings demonstrate effectiveness of a lay health worker–led symptom assessment intervention at scale for older adults with cancer.

Corresponding Author: Manali I. Patel, MD, MPH, MS, Stanford University School of Medicine, 3180 Porter Dr, Stanford, CA 94306 (manalip@stanford.edu).

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