Original Investigation

Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation

JAMA 10.1001/jama.2025.21056

November 09, 2025 at 9:45 AM EST

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Does consumption of caffeinated coffee have a beneficial, detrimental, or neutral effect on the risk of recurrent atrial fibrillation (AF) episodes?In this multicenter randomized clinical trial including 200 patients with persistent AF undergoing cardioversion, the risk of recurrent AF was significantly lower in the group allocated to coffee consumption (47%) compared with the abstinence group (64%).Consumption of coffee and other caffeinated products may be reasonably considered in patients with AF.

Corresponding Author: Gregory M. Marcus, MD, MAS, Division of Cardiology, University of California, San Francisco, 505 Parnassus Ave, M1180B, San Francisco, CA 94143 (greg.marcus@ucsf.edu).

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