Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury

For patients with severe metabolic acidosis and moderate to severe acute kidney injury, does sodium bicarbonate infusion decrease day 90 all-cause mortality?In this multicenter randomized clinical trial that included 640 patients, sodium bicarbonate infusion was not associated with lower day 90 all-cause mortality (195 of 314 patients in the bicarbonate group and 193 of 313 patients in the control group).Sodium bicarbonate infusion does not improve day 90 all-cause mortality.

Corresponding Author: Boris Jung, MD, PhD, Medical ICU, Hopital Lapeyronie, 191, Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France (b-jung@chu-montpellier.fr).

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