Review

Gastric Cancer

JAMA 10.1001/jama.2025.20034

January 07, 2026 at 11:00 AM EST

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Approximately 30 300 new cases of gastric cancer are diagnosed annually in the US. Localized gastric cancer is treated with gastrectomy, and locally advanced disease is treated with surgery and chemoimmunotherapy. For patients with unresectable or metastatic gastric cancer, chemotherapy with immune checkpoint inhibitors and targeted therapies such as trastuzumab or zolbetuximab improves survival by several months.

Corresponding Author: Haeseong Park, MD, MPH, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215 (haeseong_park@dfci.harvard.edu).

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