The Enigma of Protein Domains of Low-Sequence Complexity

In this Viewpoint, 2025 Albert Lasker Basic Medical Research Award winner Steven McKnight describes discoveries that exposed the structures and functions of low-complexity domains within protein sequences, revealing new principles of intracellular transport and cellular organization.

Corresponding Author: Steven L. McKnight, PhD, Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 (steven.mcknight@utsouthwestern.edu).

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