Individualized Prediction of Platelet Transfusion Outcomes in Preterm Infants With Severe Thrombocytopenia

When and in which preterm infants with severe thrombocytopenia do platelet transfusions reduce the risk of major bleeding or death?In a multicenter cohort of 1042 infants with severe thrombocytopenia, this study developed a decision-support algorithm estimating the absolute risks of major bleeding or mortality if prophylactic platelet transfusion were or were not to be given. Evaluation in a separate cohort (n = 637) indicated good performance.The findings show substantial variation in benefit and harm of platelet transfusion for severe thrombocytopenia, depending on the infant’s current condition. The algorithm’s risk estimates could help clinicians individualize prophylactic platelet transfusion decisions.

Corresponding Author: Johanna G. van der Bom, MD, PhD, Department of Clinical Epidemiology, Leiden University Medical Center. Albinusdreef 2, 2333 ZA Leiden, the Netherlands (j.g.vanderbom@lumc.nl).

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