Review

Geroscience

JAMA 10.1001/jama.2025.11289

August 07, 2025 at 11:00 AM EDT

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Therapies that inhibit aging biology, such as caloric restriction, metformin, senolytics, or rapalogs, may slow the development and progression of disease and functional decline in humans.

Corresponding Author: Stephen B. Kritchevsky, PhD, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University of School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157 (skritche@wakehealth.edu).

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