Review

Diverticulitis

JAMA 10.1001/jama.2025.10234

July 24, 2025 at 11:00 AM EDT

Read the full article

In the US, diverticulitis affects approximately 180 per 100 000 people annually. For uncomplicated diverticulitis, first-line therapy is observation and pain control, and antibiotics should be initiated for patients with persistent fevers, increasing leukocytosis, sepsis or septic shock, advanced age, pregnancy, immunocompromise, and certain chronic medical conditions. Treatment of complicated diverticulitis includes intravenous antibiotics, such as ceftriaxone plus metronidazole or piperacillin-tazobactam, and, if indicated, percutaneous drainage of abscess or resection of diseased segment of colon.

Corresponding Author: Anthony Charles, MD, MPH, Department of Surgery, University of Vermont, 463 Fletcher, CB 7228, Burlington, Vermont (Anthony.Charles@uvmhealth.org).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.10234?utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_term=072425

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.

Editor's Picks