JAMA_OF:03292014

Comparison of Drug-Releasing Stents Show Similar Safety Outcomes After Two Years

EMBARGOED FOR EARLY RELEASE: 9:45 A.M. (CT) MONDAY, MARCH 31, 2014 Media Advisory: To contact corresponding author Takeshi Kimura, M.D., email taketaka@kuhp.kyoto-u.ac.jp.   A comparison of the safety of biodegradable polymer biolimus-eluting stents vs durable polymer everolimus-eluting stents finds similar outcomes for measures including death and heart attack after two years, according to a JAMA…

Metformin Does Not Improve Heart Function in Patients Without Diabetes

EMBARGOED FOR EARLY RELEASE: 7 A.M. (CT) MONDAY, MARCH 31, 2014 Media Advisory: To contact corresponding author Iwan C.C. van der Horst, M.D., Ph.D., email i.c.c.van.der.horst@umcg.nl. Although some research has suggested that metformin, a medication often used in the treatment of diabetes, may have favorable effects on ventricular (heart) function, among patients without diabetes who…

Comparison of Minimally Invasive Heart Valve Systems Finds Better Device Success with Balloon-Expandable Valve

EMBARGOED FOR EARLY RELEASE: 7 A.M. (CT) SUNDAY, MARCH 30, 2014 Media Advisory: To contact Mohamed Abdel-Wahab, M.D., email mohamed.abdel-wahab@segebergerkliniken.de. To contact editorial co-author E. Murat Tuzcu, M.D., call Wyatt DuBois at 216-904-3344 or email DUBOISW@ccf.org. Among patients undergoing aortic valve replacement using a catheter tube, a comparison of two types of heart valve technologies,…

Analysis Supports Use of Risk Equations to Guide Statin Therapy

EMBARGOED FOR EARLY RELEASE: 1 P.M. (CT) SATURDAY, MARCH 29, 2014 Media Advisory: To contact Paul Muntner, Ph.D., call Nicole Wyatt at 205-934-8938 or email nwyatt@uab.edu. In an analysis of almost 11,000 patients, an assessment of equations that help guide whether a patient should begin taking a statin (cholesterol lowering medication) found that observed and…

U.S., European Cholesterol Guidelines Differ in Statin Use Recommendations

EMBARGOED FOR EARLY RELEASE: 1 P.M. (CT) SATURDAY, MARCH 29, 2014 Media Advisory: To contact Maryam Kavousi, M.D., Ph.D., email m.kavousi@erasmusmc.nl.   Application of U.S. and European cholesterol guidelines to a European population found that proportions of individuals eligible for statins differed substantially, with one U.S. guideline recommending statins for nearly all men and two-thirds…

Study Estimates Proportion of Adults Affected by New Blood Pressure Guideline

EMBARGOED FOR EARLY RELEASE: 1 P.M. (CT) SATURDAY, MARCH 29, 2014 Media Advisory: To contact Ann Marie Navar-Boggan, M.D., Ph.D., call Sarah Avery at 919-724-5343 or email sarah.avery@duke.edu. To contact editorial author Harlan M. Krumholz, M.D., S.M., call Karen Peart at 203-432-1326 or email karen.peart@yale.edu. Applying the updated 2014 blood pressure (BP) guideline to the…

JAMA:03252014

Study Finds Substantial Decrease in Use of Cardiac Imaging Procedure

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 25, 2014 Media Advisory: To contact Edward J. McNulty, M.D., call Janet Byron at 510-891-3115 or email Janet.L.Byron@kp.org. Chicago –There has been a sharp decline since 2006 in the use of nuclear myocardial perfusion imaging (MPI; an imaging procedure used to determine areas of the heart with…

Blood Glucose Measure Appears to Provide Little Benefit in Predicting Risk of Cardiovascular Disease

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 25, 2014 Media Advisory: To contact corresponding author John Danesh, F.R.C.P., email erfc@phpc.cam.ac.uk.   Chicago – In a study that included nearly 300,000 adults without a known history of diabetes or cardiovascular disease (CVD), adding information about glycated hemoglobin (HbA1c), a measure of longer-term blood sugar control,…

Greater Distance From Transplant Center Associated With Lower Likelihood of Receiving Liver Transplant, Higher Risk of Death Among U.S. Veterans

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 25, 2014 Media Advisory: To contact David S. Goldberg, M.D., M.S.C.E., call Lee-Ann Donegan at 215-349-5660 or email leeann.donegan@uphs.upenn.edu. Chicago – Among veterans meeting eligibility for liver transplantation, greater distance from a Veterans Affairs transplant center or any transplant center was associated with lower likelihood of being…

Web-based Alcohol Screening Program Shows Limited Effect Among University Students

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 25, 2014 Media Advisory: To contact Kypros Kypri, Ph.D., email kypros.kypri@newcastle.edu.au. To contact editorial co-author Timothy S. Naimi, M.D., M.P.H., call Gina DiGravio at 617-638-8480 or email gina.digravio@bmc.org. Chicago – Among university students in New Zealand, a web-based alcohol screening and brief intervention program produced a modest…

Treatment Helps Reduce Risk of Esophagus Disorder Progressing to Cancer

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 25, 2014 Media Advisory: To contact corresponding author Jacques J. Bergman, M.D., Ph.D., email j.j.bergman@amc.uva.nl. To contact editorial author Klaus Monkemuller, M.D., Ph.D., F.A.S.G.E., call Tyler Greer at 205-934-2041 or email tgreer@uab.edu.   Chicago – Among patients with the condition known as Barrett esophagus, treatment of abnormal…

JAMA_OF:03182014

Study Finds Risk of Death Among ICU Patients With Severe Sepsis Has Decreased

EMBARGOED FOR EARLY RELEASE: 3:30 A.M. (CT) TUESDAY, MARCH 18, 2014 Media Advisory: To contact corresponding author Rinaldo Bellomo, M.D., Ph.D., email Rinaldo.BELLOMO@austin.org.au. To contact editorial co-author Theodore J. Iwashyna, M.D., Ph.D., call Shantell Kirkendoll at 734-764-2220 or email SMKIRK@UMICH.EDU.   Chicago – In critically ill patients in Australia and New Zealand with severe sepsis…

JAMA:03182014

Pregnancy Associated With Greater Risk of Certain Bacterial Infection, Which May Worsen Outcomes

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 18, 2014 Media Advisory: To contact corresponding author Shamez N. Ladhani, M.R.C.P.C.H., Ph.D., email Shamez.Ladhani@phe.gov.uk. To contact editorial author Morven S. Edwards, M.D., call Glenna Picton at 713-798-7973 or email picton@bcm.edu. Chicago – In a surveillance study of infection with the bacterium Haemophilus influenzae among women of…

Children With Glomerular Kidney Disease More Likely to Have Hypertension as Adults

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 18, 2014 Media Advisory: To contact Asaf Vivante, M.D., email asafvivante@gmail.com.   Chicago – Men who as children had glomerular disease, a disorder of the portion of the kidney that filters blood and one that usually resolves with time, were more likely than men without childhood glomerular…

Using Age to Distinguish Normal From Abnormal Blood Test Results Appears to Safely Exclude Lung Blood Clots in Older Patients

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 18, 2014 Media Advisory: To contact Marc Righini, M.D., email Marc.Righini@hcuge.ch.   Chicago – Using a patient’s age to raise the threshold for an abnormal result of a blood test used to assess patients with a suspected pulmonary embolism (blood clot in lungs) appeared to be safe…

Risk of Psychiatric Diagnoses, Medication Use Increases after Critical Illness

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 18, 2014 Media Advisory: To contact corresponding author Christian F. Christiansen, M.D., Ph.D., email cc@dce.au.dk.   Chicago – Critically ill patients receiving mechanical ventilation had a higher prevalence of prior psychiatric diagnoses and an increased risk of a new psychiatric diagnosis and medication use after hospital discharge,…

JAMA:03112014

Study Examines Development of Peer Review Research in Biomedicine

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 11, 2014 Media Advisory: To contact corresponding author Ana Marusic, M.D., Ph.D., email ana.marusic@mefst.hr. To contact editorial co-author Annette Flanagin, R.N., M.A., call Jim Michalski at 312-464-5785 or email jim.michalski@jamanetwork.org.   Chicago – An analysis of research on peer review finds that studies aimed at improving methods…

Research Finds Discrepancies Between Trial Results Reported on Clinical Trial Registry and in High-Impact Journals

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 11, 2014 Media Advisory: To contact corresponding author Joseph S. Ross, M.D., M.H.S., call Karen Peart at 203-432-1326 or email karen.peart@yale.edu. Chicago – During a one year period, among clinical trials published in high-impact journals that reported results on a public clinical trial registry (ClinicalTrials.gov), nearly all…

Discontinuation of Randomized Clinical Trials Common

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 11, 2014 Media Advisory: To contact corresponding author Matthias Briel, M.D., M.Sc., email matthias.briel@usb.ch.   Chicago – Approximately 25 percent of about 1,000 randomized clinical trials initiated between 2000 and 2003 were discontinued, with the most common reason cited being poor recruitment of volunteers; and less than…

Study Finds Comparable Outcomes For Commonly Used Surgeries to Treat Vaginal Prolapse

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 11, 2014 Media Advisory: To contact Matthew D. Barber, M.D., M.H.S., call Halle Bishop Weston at 216-445-8592 or email bishoph@ccf.org. Chicago – For women undergoing surgery for vaginal prolapse and stress urinary incontinence, neither of 2 common repair procedures was superior to the other for functional or…

Findings Indicate Technical Challenges Remain Before Reliably Using Whole-Genome Sequencing For Clinical Applications

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 11, 2014 Media Advisory: To contact corresponding authors Euan A. Ashley, M.R.C.P., D.Phil., or Thomas Quertermous, M.D., call Krista Conger at 650-725-5271 or email kristac@stanford.edu. To contact editorial author William Gregory Feero, M.D., Ph.D., call 207-453-3030 or email w.gregory.feero@mainegeneral.org. Chicago – In an exploratory study involving 12…

JAMA:03042014

Study Examines Gap in Federal Oversight of Clinical Trials

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 4, 2014 Media Advisory: To contact Deborah A. Zarin, M.D., call Kathleen Cravedi at 301-496-6308 or email Kcravedi@nlm.nih.gov. Chicago – An analysis of nearly 24,000 active human research clinical trials found that between 5 percent and 16 percent fall into a regulatory gap and are not covered…

Anti-Coagulant Treatment For Atrial Fibrillation Does Not Worsen Outcomes for Patients With Kidney Disease

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 4, 2014 Media Advisory: To contact Juan Jesus Carrero, Ph.D., email Juan.Jesus.Carrero@ki.se. To contact editorial co-author Wolfgang C. Winkelmayer, M.D., M.P.H., Sc.D., call Tracie White at 650-723-7628 or email traciew@stanford.edu. Chicago – Although some research has suggested that the use of the anticoagulant warfarin for atrial fibrillation…

Opening or Expanding a Casino Associated With Lower Rate of Overweight Children in that Community

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 4, 2014 Media Advisory: To contact Jessica C. Jones-Smith, Ph.D., call Brandon Howard at 410-502-9059 or email bhoward@jhsph.edu. To contact editorial author Neal Halfon, M.D., M.P.H., call Amy Albin at 310-794-8672 or email aalbin@mednet.ucla.edu. Chicago – The opening or expansion of a casino in a community is…

Moving Out of High Poverty Appears to Affect the Mental Health of Boys, Girls Differently

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MARCH 4, 2014 Media Advisory: To contact Ronald C. Kessler, Ph.D., call David Cameron at 617-432-0441 or email david_cameron@hms.harvard.edu. Chicago – For families who moved out of high-poverty neighborhoods, boys experienced an increase and girls a decrease in rates of depression and conduct disorder, according to a study…

JAMA:02252014

Continuous Handling of Receipts Linked to Higher Urine BPA Levels

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 25, 2014 Media Advisory: To contact Shelley Ehrlich, M.D., Sc.D., M.P.H., call Jim Feuer at 513-636-4656 or email Jim.Feuer@cchmc.org.   Chicago – Study participants who handled receipts printed on thermal paper continuously for 2 hours without gloves had an increase in urine bisphenol A (BPA) concentrations compared…

Blood Transfusion For Patients Undergoing PCI Associated With Increased Risk of In-Hospital Cardiac Event

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 25, 2014 Media Advisory: To contact Matthew W. Sherwood, M.D, call Sarah Avery at 919-660-1306 or email sarah.avery@duke.edu.   Chicago – In an analysis that included more than two million patients who underwent a percutaneous coronary intervention (PCI; procedures such as balloon angioplasty or stent placement used…

Patient-Centered Medical Home Program Led to Little Improvement in Quality and No Reduction in Use of Services, Total Costs

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 25, 2014 Media Advisory: To contact Mark W. Friedberg, M.D., M.P.P., call Warren Robak at 310-451-6913 or email robak@rand.org. To contact editorial author Thomas L. Schwenk, M.D., call Anne McMillin at 775-682-9254 or email amcmillin@medicine.nevada.edu. Chicago – One of the first, largest, and longest-running multipayer trials of…

Receipt of Live MMR Vaccine Associated With Lower Rate of Infection-Related Hospital Admissions For Children

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 25, 2014 Media Advisory: To contact Signe Sorup, Ph.D., email sgs@ssi.dk. To contact editorial co-author David Goldblatt, M.B.Ch.B., Ph.D., email d.goldblatt@ucl.ac.uk.   Chicago – In a nationwide group of Danish children, receipt of the live measles, mumps, and rubella (MMR) vaccine on schedule after vaccination for other…

Obesity Prevalence Remains High in U.S.; No Significant Change in Recent Years

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 25, 2014 Media Advisory: To contact Cynthia L. Ogden, Ph.D., email Jeff Lancashire (jhl1@cdc.gov) or the CDC press office (paoquery@cdc.gov) or call 301-458-4800. Chicago – The prevalence of obesity remains high in the U.S., with about one-third of adults and 17 percent of children and teens obese…

JAMA:02182014

Study Finds Low Rate of Surgical Site Infections Following Ambulatory Surgery

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 18, 2014 Media Advisory: To contact corresponding author Claudia A. Steiner, M.D., M.P.H., call Alison Hunt at 301-427-1244 or email Alison.Hunt@ahrq.hhs.gov. Chicago – In an analysis that included nearly 300,000 patients from eight states who underwent ambulatory surgery (surgery performed on a person who is admitted to…

Study Examines Public Awareness, Use of Online Physician Rating Sites

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 18, 2014 Media Advisory: To contact David A. Hanauer, M.D., M.S., call Mary Masson at 734-764-2220 or email mfmasson@med.umich.edu. Chicago – In a survey of a nationally representative sample of the U.S. population, 65 percent of respondents reported awareness of online physician ratings and about one-fourth reported…

Treatment Using Electrical Energy, Instead of Medications, May Be Viable First Option for Treating Certain Type of Atrial Fibrillation

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 18, 2014 Media Advisory: To contact Carlos A. Morillo, M.D., F.R.C.P.C., call Veronica McGuire at 905-525-9140, ext. 22169, or email vmcguir@mcmaster.ca. To contact editorial co-author Hugh Calkins, M.D., call Stephanie Desmon at 410-955-8665 or email sdesmon1@jhmi.edu.   Chicago – Among patients with untreated paroxysmal (intermittent) atrial fibrillation…

Medication to Treat Agitation for Alzheimer Disease Shows Mixed Results

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 18, 2014 Media Advisory: To contact Anton P. Porsteinsson, M.D., call Julie Philipp at 585-275-1309 or email Julie_Philipp@urmc.rochester.edu. To contact editorial author Gary W. Small, M.D., call Rachel Champeau at 310-794-2270 or email rchampeau@mednet.ucla.edu. Chicago – The use of the medication citalopram was associated with a reduction…

Home-Based Exercise Program Improves Recovery Following Rehabilitation for Hip Fracture

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 18, 2014 Media Advisory: To contact Nancy K. Latham, Ph.D., P.T., call Lisa Chedekel at 617-571-6370 or email chedekel@bu.edu. Chicago – Among patients who had completed standard rehabilitation after hip fracture, the use of a home exercise program that included exercises such as standing from a chair…

JAMA: 02112014

Study Examines Legislative Challenges to School Immunization Mandates

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 11, 2014 Media Advisory: To contact Saad B. Omer, M.B.B.S., M.P.H., Ph.D., call Melva Robertson at 404-727-5692 or email melva.robertson@emory.edu. Chicago – From 2009-2012, 36 bills introduced in 18 states sought to modify school immunization mandates, with the majority seeking to expand exemptions although none of the…

Hospital Readmission Rate Varies Following Care at Rehabilitation Facility

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 11, 2014 Media Advisory: To contact Kenneth J. Ottenbacher, Ph.D., call Molly Dannenmaier at 409-772-8790 or email mjdannen@utmb.edu; or Mechal Weiss at 212-642-7731, mechal.weiss@edelman.com.  Chicago – Among rehabilitation facilities providing services to Medicare fee-for-service patients, 30-day hospital readmission rates vary, from about 6 percent for patients with…

Fewer Doses of HPV Vaccine Still Results in Reduced Risk of STD

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 11, 2014 Media Advisory: To contact corresponding author Lisen Arnheim-Dahlström, Ph.D., email lisen.arnheim.dahlstrom@ki.se. Chicago – Although maximum reduction in the risk of genital warts (condylomata) was seen after 3 doses of human papillomavirus (HPV) vaccine, receipt of 2 vaccine doses was associated with considerable reduction in risk,…

Preterm Infants More Likely to Have Elevated Insulin Levels in Early Childhood

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 11, 2014 Media Advisory: To contact corresponding author Xiaobin Wang, M.D., M.P.H., Sc.D., call Tim Parsons at 410-955-7619 or email tmparson@jhsph.edu. To contact editorial author Mark Hanson, D.Phil., F.R.C.O.G., email M.Hanson@soton.ac.uk. Chicago – Researchers have found that preterm infants are more likely to have elevated insulin levels…

Study Finds Small Increased Risk of Kidney Disease Following Kidney Donation

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 11, 2014 Media Advisory: To contact corresponding author Dorry L. Segev, M.D., Ph.D., call Stephanie Desmon at 410-955-8665 or email sdesmon1@jhmi.edu. To contact editorial co-author John S. Gill, M.D., call Brian Kladko at 604-827-3301 or email brian.kladko@ubc.ca.   Chicago – An analysis of nearly 100,000 kidney donors…

JAMA:02042014

Pre-Term Infants with Severe Retinopathy More Likely to Have Non-Visual Disabilities at Age 5

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 4, 2014 Media Advisory: To contact Barbara Schmidt, M.D., M.Sc., call Alison Fraser at 267-426-6054 or email FraserA1@email.chop.edu. Chicago – In a group of very low-birth-weight infants, severe retinopathy of prematurity was associated with nonvisual disabilities at age 5 years, according to a study in the February…

Non-Invasive Measure of Heart Tissue Scarring May Be Useful For Determining Patients Most Suitable For Procedure for Irregular Heart Beat

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 4, 2014 Media Advisory: To contact Nassir F. Marrouche, M.D., call Phil Sahm at 801-581-2517 or email phil.sahm@hsc.utah.edu. Chicago – Scarring of tissue in the upper chamber of the heart (atrium) was associated with recurrent rhythm disorder after treatment, according to a study in the February 5…

Pattern of Higher Blood Pressure in Early Adulthood Helps Predict Risk of Atherosclerosis in Middle-Age

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 4, 2014 Media Advisory: To contact Norrina B. Allen, Ph.D., M.P.H., call Marla Paul at 312-503-8928 or email marla-paul@northwestern.edu. To contact editorial co-author George L. Bakris, M.D., call John Easton at 773-795-5225 or email john.easton@uchospitals.edu. Chicago – In an analysis of blood pressure patterns over a 25-year…

JAMA_OF:01212014

Oral History Examines Origins, Development and Future of Evidence-Based Medicine

EMBARGOED FOR EARLY RELEASE: 8 A.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact Richard Smith, M.B.Ch.B., C.B.E., email richardswsmith@yahoo.co.uk.   Chicago – A video of individuals who gave birth to the evidence-based medicine movement features valuable oral histories of the movement, according to an editorial in the January 22/29 issue of JAMA. Evidence-based…

JAMA:01212014

Biomarkers in Blood Show Potential As Early Detection Method of Pancreatic Cancer

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact corresponding author Julia S. Johansen, M.D., D.M.Sc., email julia.johansen@post3.tele.dk. To contact editorial co-author Donald J. Buchsbaum, Ph.D., email Beena Thannickal at beenat@uab.edu. Chicago – Researchers have identified diagnostic microRNA panels in whole blood that had the ability to distinguish, to some…

Mediterranean Diet Associated With Lower Risk of Peripheral Artery Disease

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact corresponding author Miguel A. Martinez-Gonzalez, M.D., M.P.H., Ph.D., email mamartinez@unav.es.   Chicago – A multicenter study that previously reported a reduction in heart attack and stroke with a Mediterranean diet supplemented with extra-virgin olive oil or with nuts now also reports…

Study Examines Reasons for Delay, Denial of New Drugs by FDA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact Leonard V. Sacks, M.B.B.Ch., call Sandy Walsh at 301-796-4669 or email sandy.walsh@fda.hhs.gov. Chicago – Several potentially preventable deficiencies, including failure to select optimal drug doses and suitable outcome measures for a study, accounted for significant delays in the approval of new…

Many Cardiovascular Devices Approved by Process That Often Does Not Require New Clinical Data

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact corresponding author Aaron S. Kesselheim, M.D., J.D., M.P.H., call Jessica Maki at 617-525-6373 or email jmaki3@partners.org.   Chicago – Many cardiac implantable electronic device models currently in use were approved via a Food and Drug Administration review process in which the…

Wide Variation Found in Quality of Evidence Used By FDA For Approval of New Drugs

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact corresponding author Joseph S. Ross, M.D., M.H.S., call Karen Peart at 203-432-1326 or email karen.peart@yale.edu. To contact editorial co-author Steven N. Goodman, M.D., M.H.S., Ph.D., call Ruthann Richter at 650-725-8047 or email richter1@stanford.edu. Chicago – Clinical trials used by the Food…

JAMA:01142014

Patients With Mild Hyperglycemia and Genetic Mutation Have Low Prevalence of Vascular Complications

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 14, 2014 Media Advisory: To contact corresponding author Andrew T. Hattersley, D.M., email a.t.hattersley@exeter.ac.uk. To contact editorial author Jose C. Florez, M.D., Ph.D., call Mike Morrison at 617-724-6425 or email mdmorrison@partners.org. Chicago – Despite having mild hyperglycemia for approximately 50 years, patients with a mutation in the…

Follow-up Tests Improve Colorectal Cancer Recurrence Detection

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 14, 2014 Media Advisory: To contact corresponding author John N. Primrose, M.D., F.R.C.S., email j.n.primrose@soton.ac.uk. Chicago – Among patients who had undergone curative surgery for primary colorectal cancer, the screening methods of computed tomography and carcinoembryonic antigen each provided an improved rate of surgical treatment of cancer…

JAMA:01072014

Study Examines Prevalence of Smoking Among Health Care Professionals

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact Linda Sarna, Ph.D., R.N., call Laura Perry at 818-212-6226 or email Lperry@sonnet.ucla.edu.   Chicago – A survey of health care professionals finds that in 2010-2011, current smoking among this group, except for licensed practical nurses, was lower than the general population,…

Longer-Term Use of Smoking Cessation Medication Effective Among Patients With Mental Illness

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact A. Eden Evins, M.D., M.P.H., email Kristen Chadwick at kschadwick@partners.org. Chicago – Among smokers with schizophrenia or bipolar disease who achieved initial smoking abstinence with a standard 12-week course of the smoking cessation drug varenicline, an additional 40 weeks of treatment…

Combination Therapy Shows Short-Term Benefit, But Does Not Improve Ability to Quit Smoking After One Year

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact Jon O. Ebbert, M.D., M.Sc., call Kelley Luckstein at 507-284-5005 or email luckstein.kelley@mayo.edu. Chicago – Among cigarette smokers, the combined use of the smoking cessation medications varenicline and bupropion, compared with varenicline alone, resulted in better rates of smoking abstinence at…

Adults With Mental Illness Have Lower Rate of Decline in Smoking

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact Benjamin Lê Cook, Ph.D., M.P.H., call David Cecere at 617-591-4044 or email dcecere@challiance.org. Chicago – In recent years, the decline in smoking among individuals with mental illness was significantly less than among those without mental illness, although the rates of quitting…

Overall Prevalence of Smoking Has Decreased Globally, Although Number of Smokers, Cigarettes Consumed, Has Increased

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact corresponding author Christopher J.L. Murray, M.D., D.Phil., call Rhonda Stewart at 206-897-2863 or email stewartr@uw.edu. Chicago – Since 1980, the global prevalence of daily tobacco smoking has declined by an estimated 25 percent for men and 42 percent for women, although…

Study Estimates Tobacco Control in U.S. Has Saved 8 Million Lives In Last 50 Years

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact Theodore R. Holford, Ph.D., call Helen Dodson at 203-436-3984 or email helen.dodson@yale.edu. Chicago – Researchers estimate that tobacco control in the U.S. since 1964 has been associated with the avoidance of an estimated 8 million premature smoking-attributable deaths, with the beneficiaries…

JAMA:12312013

Study Identifies Factors Associated With Pain One Year After Breast Cancer Surgery

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 31, 2013 Media Advisory: To contact Tuomo J. Meretoja, M.D., Ph.D., email tuomo.meretoja@fimnet.fi.   Chicago – In a study that included more than 800 women who had undergone surgery for breast cancer, the majority reported some level of pain 12 months after surgery, and factors associated with…

Use of Vitamin E By Patients With Mild to Moderate Alzheimer Disease Slows Functional Decline

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 31, 2013 Media Advisory: To contact Maurice W. Dysken, M.D., call Ralph Heussner at 612-467-3012 or email Ralph.Heussner@va.gov. To contact editorial co-author Denis A. Evans, M.D., email Deb Song at Deb_Song@rush.edu.   Chicago – Among patients with mild to moderate Alzheimer disease, a daily dosage of 2,000…

JAMA:12242013

Nonsteroidal Anti-Inflammatory Agent Slows Rate of Progression of Neurodegenerative Disease

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 24, 2013 Media Advisory: To contact John L. Berk, M.D., call Jenny Eriksen Leary at 617-638-6841 or email jenny.eriksen@bmc.org. Chicago – Among patients with familial amyloid polyneuropathy, a lethal, genetic neurodegenerative disease, use of the nonsteroidal anti-inflammatory agent diflunisal compared with placebo for 2 years reduced the…

Use of Antidepressant Does Not Improve Symptoms From Stomach Disorder

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 24, 2013 Media Advisory: To contact Henry P. Parkman, M.D., call Kathleen Duffy at 267-800-4359 or email Kathleen.Duffy@tuhs.temple.edu. Chicago – Among patients with idiopathic (of unknown cause) gastroparesis, use of the antidepressant nortriptyline compared with placebo for 15 weeks did not result in improvement in overall symptoms,…

Proportion of Opioid Treatment Programs Offering On-Site Testing For HIV and STIs Declines Substantially

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 24, 2013 Media Advisory: To contact Chinazo O. Cunningham, M.D., M.S., call Kim Newman at 718-430-3101 or email Sciencenews@einstein.yu.edu. Chicago – A survey of opioid treatment programs finds that the proportion offering on-site testing for human immunodeficiency virus (HIV) and sexually transmitted infections (STIs) declined substantially between…

Adding Cognitive Behavioral Therapy to Treatment of Pediatric Migraine Improves Relief of Symptoms

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 24, 2013 Media Advisory: To contact Scott W. Powers, Ph.D., call Jim Feuer at 513-636-4656 or email Jim.Feuer@cchmc.org. To contact editorial author Mark Connelly, Ph.D., call Jessica Salazar at 816-346-1346 or email jmsalazar@cmh.edu. Chicago – Among children and adolescents with chronic migraine, the use of cognitive behavioral…

Multi-Component Therapy Shown Beneficial in Treating PTSD in Adolescent Girls

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 24, 2013 Media Advisory: To contact Edna B. Foa, Ph.D., call Steve Graff at 215-349-5653 or email Stephen.Graff@uphs.upenn.edu. To contact Sean Perrin, Ph.D., email sean.perrin@psy.lu.se. Chicago – Adolescents girls with sexual abuse-related posttraumatic stress disorder (PTSD) experienced greater benefit from prolonged exposure therapy (a type of therapy…

JAMA_OF:12182013

New Guidelines for Management of High Blood Pressure Released

EMBARGOED FOR EARLY RELEASE: 10 A.M. (CT) WEDNESDAY, DECEMBER 18, 2013 Media Advisory: To contact corresponding author Paul A. James, M.D., call Molly Rossiter at 319-356-7127 or email molly-rossiter@uiowa.edu. Chicago – A new guideline for the management of high blood pressure, developed by an expert panel and containing nine recommendations and a treatment algorithm (flow…

JAMA:12172013

Nonsurgical Treatment of Periodontitis For Persons With Diabetes Does Not Improve Glycemic Control

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 17, 2013 Media Advisory: To contact Steven P. Engebretson, D.M.D., M.S., M.S., call Elyse Bloom at 212-998-9910 or email dental.communications@nyu.edu. Chicago – For persons with type 2 diabetes and chronic periodontitis, nonsurgical periodontal treatment did not result in improved glycemic control, according to a study appearing in…

Study Assesses Amount, Patterns of Sedentary Behavior of Older Women

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 17, 2013 Media Advisory: To contact Eric J. Shiroma, M.Ed., M.S., call Jessica Maki at 617-525-6373 or email jmaki3@partners.org. Chicago – Among 7,000 older women who wore an accelerometer to measure their movement, about two-thirds of their waking time was spent in sedentary behavior, most of which…

Medical Communication Companies Receive Substantial Support From Drug and Device Companies

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 17, 2013 Media Advisory: To contact Sheila M. Rothman, Ph.D., call Whitney Adair at 212-342-5268 or email smr4@columbia.edu or wa2187@columbia.edu. To contact editorial co-author Steven Woloshin, M.D., M.S., call Mike Barwell at 603-653-1984 or email Michael.r.barwell@hitchcock.org. Chicago – Eighteen medical communication companies (MCCs) received about $100 million…

JAMA:12102013

Use of CPAP for Sleep Apnea Reduces Blood Pressure for Patients With Difficult to Treat Hypertension

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 10, 2013 Media Advisory: To contact Miguel-Angel Martinez-Garcia, M.D., Ph.D., email mianmartinezgarcia@gmail.com. Chicago – Among patients with obstructive sleep apnea and hypertension that requires 3 or more medications to control, continuous positive airway pressure (CPAP) treatment for 12 weeks resulted in a decrease in 24-hour average and…

Acid-Suppressing Medications Associated with Vitamin B12 Deficiency

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 10, 2013 Media Advisory: To contact corresponding author Douglas A. Corley, M.D., Ph.D., call Janet Byron at 510-891-3115 or email Janet.L.Byron@kp.org. Chicago – Use for 2 or more years of proton pump inhibitors and histamine 2 receptor antagonists (two types of acid-inhibiting medications) was associated with a…

JAMA:12032013

Simulation-Based Communication Training Does Not Improve Quality of End-of-Life Care

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 3, 2013 Media Advisory: To contact J. Randall Curtis, M.D., M.P.H., call Elizabeth Hunter at 206-616-3192 or email elh415@uw.edu. To contact editorial co-author Abraham Verghese, M.D., call Margarita Gallardo at 650-723-7897 or email mjgallardo@stanford.edu. Chicago – Among internal medicine and nurse practitioner trainees, simulation-based communication skills training…

Attending Clinical and Tutorial-Based Activities By Medical Students Associated With Better Overall Examination Scores

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 3, 2013 Media Advisory: To contact Richard P. Deane, M.B., B.Ch., email deaneri@tcd.ie. Chicago – Among fourth-year medical students completing an 8-week obstetrics/gynecology clinical rotation, there was a positive association between attendance at clinical and tutorial-based activities and overall examination scores, according to a study appearing in…

Study Examines Incidence, Trend of Substance Use Disorder Among Medical Residents

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 3, 2013 Media Advisory: To contact David O. Warner, M.D., call Bryan Anderson at 507-284-5005 or email Anderson.bryan@mayo.edu. Chicago – Among anesthesiology residents entering primary training from 1975 to 2009, 0.86 percent had a confirmed substance use disorder during training, with the incidence of this disorder increasing…

Diversity Initiatives Do Not Appear to Increase Representation of Minorities on Faculty of Medical Schools

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 3, 2013 Media Advisory: To contact James Guevara, M.D., M.P.H., call Dana Weidig at 267-426-6092 or email weidigd@email.chop.edu. Chicago – From 2000 to 2010, the presence of a minority faculty development program at U.S. medical schools was not associated with greater underrepresented minority faculty representation, recruitment, or…

Multifaceted Program to Improve Patient Continuity of Care in Hospitals Associated With Reduction in Medical Errors

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 3, 2013 Media Advisory: To contact Amy J. Starmer, M.D., M.P.H., call Meghan Weber at 617-919-3110 or email Meghan.Weber@childrens.harvard.edu. To contact editorial author Leora Horwitz, M.D., M.H.S., call Helen Dodson at 203-436-3984 or email helen.dodson@yale.edu. Chicago – Implementation of a multifaceted program to improve patient handoffs (change…

JAMA:11262013

Prevalence of Undiagnosed HIV Infection Low Among State Prison Entrants

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 26, 2013 Media Advisory: To contact David Alain Wohl, M.D., call Lisa Chensvold at 919-843-5719 or email lisa_chensvold@med.unc.edu. Chicago – An analysis indicates that the prevalence of undiagnosed human immunodeficiency virus (HIV) infection among state prison entrants in North Carolina was low, at 0.09 percent, according to…

Induced Hypothermia Does Not Improve Outcomes for Patients With Severe Bacterial Meningitis; May Be Harmful

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 26, 2013 Media Advisory: To contact Bruno Mourvillier, M.D., email bruno.mourvillier@bch.aphp.fr. Chicago – In a study of adults with severe bacterial meningitis, therapeutic hypothermia (reduction of body temperature) did not improve outcomes, and it may even have been harmful, according to a study appearing in the November…

Study Finds No Increased Risk of Retinal Detachment With Use of Certain Antibiotics

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 26, 2013 Media Advisory: To contact Bjorn Pasternak, M.D., Ph.D., email bjp@ssi.dk. To contact editorial author Allan S. Brett, M.D., call Jeff Stensland at 803-777-3686 or email stenslan@mailbox.sc.edu. Chicago – In contrast to findings of a recent study, researchers in Denmark did not find an association between…