Study Examines Legislative Challenges to School Immunization Mandates

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 11, 2014 Media Advisory: To contact Saad B. Omer, M.B.B.S., M.P.H., Ph.D., call Melva Robertson at 404-727-5692 or email melva.robertson@emory.edu. Chicago – From 2009-2012, 36 bills introduced in 18 states sought to modify school immunization mandates, with the majority seeking to expand exemptions although none of the…

Hospital Readmission Rate Varies Following Care at Rehabilitation Facility

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 11, 2014 Media Advisory: To contact Kenneth J. Ottenbacher, Ph.D., call Molly Dannenmaier at 409-772-8790 or email mjdannen@utmb.edu; or Mechal Weiss at 212-642-7731, mechal.weiss@edelman.com.  Chicago – Among rehabilitation facilities providing services to Medicare fee-for-service patients, 30-day hospital readmission rates vary, from about 6 percent for patients with…

Fewer Doses of HPV Vaccine Still Results in Reduced Risk of STD

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 11, 2014 Media Advisory: To contact corresponding author Lisen Arnheim-Dahlström, Ph.D., email lisen.arnheim.dahlstrom@ki.se. Chicago – Although maximum reduction in the risk of genital warts (condylomata) was seen after 3 doses of human papillomavirus (HPV) vaccine, receipt of 2 vaccine doses was associated with considerable reduction in risk,…

Preterm Infants More Likely to Have Elevated Insulin Levels in Early Childhood

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 11, 2014 Media Advisory: To contact corresponding author Xiaobin Wang, M.D., M.P.H., Sc.D., call Tim Parsons at 410-955-7619 or email tmparson@jhsph.edu. To contact editorial author Mark Hanson, D.Phil., F.R.C.O.G., email M.Hanson@soton.ac.uk. Chicago – Researchers have found that preterm infants are more likely to have elevated insulin levels…

Study Finds Small Increased Risk of Kidney Disease Following Kidney Donation

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 11, 2014 Media Advisory: To contact corresponding author Dorry L. Segev, M.D., Ph.D., call Stephanie Desmon at 410-955-8665 or email sdesmon1@jhmi.edu. To contact editorial co-author John S. Gill, M.D., call Brian Kladko at 604-827-3301 or email brian.kladko@ubc.ca.   Chicago – An analysis of nearly 100,000 kidney donors…

JAMA:02042014

Pre-Term Infants with Severe Retinopathy More Likely to Have Non-Visual Disabilities at Age 5

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 4, 2014 Media Advisory: To contact Barbara Schmidt, M.D., M.Sc., call Alison Fraser at 267-426-6054 or email FraserA1@email.chop.edu. Chicago – In a group of very low-birth-weight infants, severe retinopathy of prematurity was associated with nonvisual disabilities at age 5 years, according to a study in the February…

Non-Invasive Measure of Heart Tissue Scarring May Be Useful For Determining Patients Most Suitable For Procedure for Irregular Heart Beat

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 4, 2014 Media Advisory: To contact Nassir F. Marrouche, M.D., call Phil Sahm at 801-581-2517 or email phil.sahm@hsc.utah.edu. Chicago – Scarring of tissue in the upper chamber of the heart (atrium) was associated with recurrent rhythm disorder after treatment, according to a study in the February 5…

Pattern of Higher Blood Pressure in Early Adulthood Helps Predict Risk of Atherosclerosis in Middle-Age

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, FEBRUARY 4, 2014 Media Advisory: To contact Norrina B. Allen, Ph.D., M.P.H., call Marla Paul at 312-503-8928 or email marla-paul@northwestern.edu. To contact editorial co-author George L. Bakris, M.D., call John Easton at 773-795-5225 or email john.easton@uchospitals.edu. Chicago – In an analysis of blood pressure patterns over a 25-year…

JAMA_OF:01212014

Oral History Examines Origins, Development and Future of Evidence-Based Medicine

EMBARGOED FOR EARLY RELEASE: 8 A.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact Richard Smith, M.B.Ch.B., C.B.E., email richardswsmith@yahoo.co.uk.   Chicago – A video of individuals who gave birth to the evidence-based medicine movement features valuable oral histories of the movement, according to an editorial in the January 22/29 issue of JAMA. Evidence-based…

JAMA:01212014

Biomarkers in Blood Show Potential As Early Detection Method of Pancreatic Cancer

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact corresponding author Julia S. Johansen, M.D., D.M.Sc., email julia.johansen@post3.tele.dk. To contact editorial co-author Donald J. Buchsbaum, Ph.D., email Beena Thannickal at beenat@uab.edu. Chicago – Researchers have identified diagnostic microRNA panels in whole blood that had the ability to distinguish, to some…

Mediterranean Diet Associated With Lower Risk of Peripheral Artery Disease

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact corresponding author Miguel A. Martinez-Gonzalez, M.D., M.P.H., Ph.D., email mamartinez@unav.es.   Chicago – A multicenter study that previously reported a reduction in heart attack and stroke with a Mediterranean diet supplemented with extra-virgin olive oil or with nuts now also reports…

Study Examines Reasons for Delay, Denial of New Drugs by FDA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact Leonard V. Sacks, M.B.B.Ch., call Sandy Walsh at 301-796-4669 or email sandy.walsh@fda.hhs.gov. Chicago – Several potentially preventable deficiencies, including failure to select optimal drug doses and suitable outcome measures for a study, accounted for significant delays in the approval of new…

Many Cardiovascular Devices Approved by Process That Often Does Not Require New Clinical Data

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact corresponding author Aaron S. Kesselheim, M.D., J.D., M.P.H., call Jessica Maki at 617-525-6373 or email jmaki3@partners.org.   Chicago – Many cardiac implantable electronic device models currently in use were approved via a Food and Drug Administration review process in which the…

Wide Variation Found in Quality of Evidence Used By FDA For Approval of New Drugs

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 21, 2014 Media Advisory: To contact corresponding author Joseph S. Ross, M.D., M.H.S., call Karen Peart at 203-432-1326 or email karen.peart@yale.edu. To contact editorial co-author Steven N. Goodman, M.D., M.H.S., Ph.D., call Ruthann Richter at 650-725-8047 or email richter1@stanford.edu. Chicago – Clinical trials used by the Food…

JAMA:01142014

Patients With Mild Hyperglycemia and Genetic Mutation Have Low Prevalence of Vascular Complications

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 14, 2014 Media Advisory: To contact corresponding author Andrew T. Hattersley, D.M., email a.t.hattersley@exeter.ac.uk. To contact editorial author Jose C. Florez, M.D., Ph.D., call Mike Morrison at 617-724-6425 or email mdmorrison@partners.org. Chicago – Despite having mild hyperglycemia for approximately 50 years, patients with a mutation in the…

Follow-up Tests Improve Colorectal Cancer Recurrence Detection

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 14, 2014 Media Advisory: To contact corresponding author John N. Primrose, M.D., F.R.C.S., email j.n.primrose@soton.ac.uk. Chicago – Among patients who had undergone curative surgery for primary colorectal cancer, the screening methods of computed tomography and carcinoembryonic antigen each provided an improved rate of surgical treatment of cancer…

JAMA:01072014

Study Examines Prevalence of Smoking Among Health Care Professionals

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact Linda Sarna, Ph.D., R.N., call Laura Perry at 818-212-6226 or email Lperry@sonnet.ucla.edu.   Chicago – A survey of health care professionals finds that in 2010-2011, current smoking among this group, except for licensed practical nurses, was lower than the general population,…

Longer-Term Use of Smoking Cessation Medication Effective Among Patients With Mental Illness

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact A. Eden Evins, M.D., M.P.H., email Kristen Chadwick at kschadwick@partners.org. Chicago – Among smokers with schizophrenia or bipolar disease who achieved initial smoking abstinence with a standard 12-week course of the smoking cessation drug varenicline, an additional 40 weeks of treatment…

Combination Therapy Shows Short-Term Benefit, But Does Not Improve Ability to Quit Smoking After One Year

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact Jon O. Ebbert, M.D., M.Sc., call Kelley Luckstein at 507-284-5005 or email luckstein.kelley@mayo.edu. Chicago – Among cigarette smokers, the combined use of the smoking cessation medications varenicline and bupropion, compared with varenicline alone, resulted in better rates of smoking abstinence at…

Adults With Mental Illness Have Lower Rate of Decline in Smoking

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact Benjamin Lê Cook, Ph.D., M.P.H., call David Cecere at 617-591-4044 or email dcecere@challiance.org. Chicago – In recent years, the decline in smoking among individuals with mental illness was significantly less than among those without mental illness, although the rates of quitting…

Overall Prevalence of Smoking Has Decreased Globally, Although Number of Smokers, Cigarettes Consumed, Has Increased

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact corresponding author Christopher J.L. Murray, M.D., D.Phil., call Rhonda Stewart at 206-897-2863 or email stewartr@uw.edu. Chicago – Since 1980, the global prevalence of daily tobacco smoking has declined by an estimated 25 percent for men and 42 percent for women, although…

Study Estimates Tobacco Control in U.S. Has Saved 8 Million Lives In Last 50 Years

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 7, 2014 Media Advisory: To contact Theodore R. Holford, Ph.D., call Helen Dodson at 203-436-3984 or email helen.dodson@yale.edu. Chicago – Researchers estimate that tobacco control in the U.S. since 1964 has been associated with the avoidance of an estimated 8 million premature smoking-attributable deaths, with the beneficiaries…

JAMA:12312013

Study Identifies Factors Associated With Pain One Year After Breast Cancer Surgery

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 31, 2013 Media Advisory: To contact Tuomo J. Meretoja, M.D., Ph.D., email tuomo.meretoja@fimnet.fi.   Chicago – In a study that included more than 800 women who had undergone surgery for breast cancer, the majority reported some level of pain 12 months after surgery, and factors associated with…

Use of Vitamin E By Patients With Mild to Moderate Alzheimer Disease Slows Functional Decline

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 31, 2013 Media Advisory: To contact Maurice W. Dysken, M.D., call Ralph Heussner at 612-467-3012 or email Ralph.Heussner@va.gov. To contact editorial co-author Denis A. Evans, M.D., email Deb Song at Deb_Song@rush.edu.   Chicago – Among patients with mild to moderate Alzheimer disease, a daily dosage of 2,000…

JAMA:12242013

Nonsteroidal Anti-Inflammatory Agent Slows Rate of Progression of Neurodegenerative Disease

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 24, 2013 Media Advisory: To contact John L. Berk, M.D., call Jenny Eriksen Leary at 617-638-6841 or email jenny.eriksen@bmc.org. Chicago – Among patients with familial amyloid polyneuropathy, a lethal, genetic neurodegenerative disease, use of the nonsteroidal anti-inflammatory agent diflunisal compared with placebo for 2 years reduced the…

Use of Antidepressant Does Not Improve Symptoms From Stomach Disorder

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 24, 2013 Media Advisory: To contact Henry P. Parkman, M.D., call Kathleen Duffy at 267-800-4359 or email Kathleen.Duffy@tuhs.temple.edu. Chicago – Among patients with idiopathic (of unknown cause) gastroparesis, use of the antidepressant nortriptyline compared with placebo for 15 weeks did not result in improvement in overall symptoms,…

Proportion of Opioid Treatment Programs Offering On-Site Testing For HIV and STIs Declines Substantially

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 24, 2013 Media Advisory: To contact Chinazo O. Cunningham, M.D., M.S., call Kim Newman at 718-430-3101 or email Sciencenews@einstein.yu.edu. Chicago – A survey of opioid treatment programs finds that the proportion offering on-site testing for human immunodeficiency virus (HIV) and sexually transmitted infections (STIs) declined substantially between…

Adding Cognitive Behavioral Therapy to Treatment of Pediatric Migraine Improves Relief of Symptoms

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 24, 2013 Media Advisory: To contact Scott W. Powers, Ph.D., call Jim Feuer at 513-636-4656 or email Jim.Feuer@cchmc.org. To contact editorial author Mark Connelly, Ph.D., call Jessica Salazar at 816-346-1346 or email jmsalazar@cmh.edu. Chicago – Among children and adolescents with chronic migraine, the use of cognitive behavioral…

Multi-Component Therapy Shown Beneficial in Treating PTSD in Adolescent Girls

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 24, 2013 Media Advisory: To contact Edna B. Foa, Ph.D., call Steve Graff at 215-349-5653 or email Stephen.Graff@uphs.upenn.edu. To contact Sean Perrin, Ph.D., email sean.perrin@psy.lu.se. Chicago – Adolescents girls with sexual abuse-related posttraumatic stress disorder (PTSD) experienced greater benefit from prolonged exposure therapy (a type of therapy…

JAMA_OF:12182013

New Guidelines for Management of High Blood Pressure Released

EMBARGOED FOR EARLY RELEASE: 10 A.M. (CT) WEDNESDAY, DECEMBER 18, 2013 Media Advisory: To contact corresponding author Paul A. James, M.D., call Molly Rossiter at 319-356-7127 or email molly-rossiter@uiowa.edu. Chicago – A new guideline for the management of high blood pressure, developed by an expert panel and containing nine recommendations and a treatment algorithm (flow…

JAMA:12172013

Nonsurgical Treatment of Periodontitis For Persons With Diabetes Does Not Improve Glycemic Control

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 17, 2013 Media Advisory: To contact Steven P. Engebretson, D.M.D., M.S., M.S., call Elyse Bloom at 212-998-9910 or email dental.communications@nyu.edu. Chicago – For persons with type 2 diabetes and chronic periodontitis, nonsurgical periodontal treatment did not result in improved glycemic control, according to a study appearing in…

Study Assesses Amount, Patterns of Sedentary Behavior of Older Women

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 17, 2013 Media Advisory: To contact Eric J. Shiroma, M.Ed., M.S., call Jessica Maki at 617-525-6373 or email jmaki3@partners.org. Chicago – Among 7,000 older women who wore an accelerometer to measure their movement, about two-thirds of their waking time was spent in sedentary behavior, most of which…

Medical Communication Companies Receive Substantial Support From Drug and Device Companies

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 17, 2013 Media Advisory: To contact Sheila M. Rothman, Ph.D., call Whitney Adair at 212-342-5268 or email smr4@columbia.edu or wa2187@columbia.edu. To contact editorial co-author Steven Woloshin, M.D., M.S., call Mike Barwell at 603-653-1984 or email Michael.r.barwell@hitchcock.org. Chicago – Eighteen medical communication companies (MCCs) received about $100 million…

JAMA:12102013

Use of CPAP for Sleep Apnea Reduces Blood Pressure for Patients With Difficult to Treat Hypertension

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 10, 2013 Media Advisory: To contact Miguel-Angel Martinez-Garcia, M.D., Ph.D., email mianmartinezgarcia@gmail.com. Chicago – Among patients with obstructive sleep apnea and hypertension that requires 3 or more medications to control, continuous positive airway pressure (CPAP) treatment for 12 weeks resulted in a decrease in 24-hour average and…

Acid-Suppressing Medications Associated with Vitamin B12 Deficiency

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 10, 2013 Media Advisory: To contact corresponding author Douglas A. Corley, M.D., Ph.D., call Janet Byron at 510-891-3115 or email Janet.L.Byron@kp.org. Chicago – Use for 2 or more years of proton pump inhibitors and histamine 2 receptor antagonists (two types of acid-inhibiting medications) was associated with a…

JAMA:12032013

Simulation-Based Communication Training Does Not Improve Quality of End-of-Life Care

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 3, 2013 Media Advisory: To contact J. Randall Curtis, M.D., M.P.H., call Elizabeth Hunter at 206-616-3192 or email elh415@uw.edu. To contact editorial co-author Abraham Verghese, M.D., call Margarita Gallardo at 650-723-7897 or email mjgallardo@stanford.edu. Chicago – Among internal medicine and nurse practitioner trainees, simulation-based communication skills training…

Attending Clinical and Tutorial-Based Activities By Medical Students Associated With Better Overall Examination Scores

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 3, 2013 Media Advisory: To contact Richard P. Deane, M.B., B.Ch., email deaneri@tcd.ie. Chicago – Among fourth-year medical students completing an 8-week obstetrics/gynecology clinical rotation, there was a positive association between attendance at clinical and tutorial-based activities and overall examination scores, according to a study appearing in…

Study Examines Incidence, Trend of Substance Use Disorder Among Medical Residents

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 3, 2013 Media Advisory: To contact David O. Warner, M.D., call Bryan Anderson at 507-284-5005 or email Anderson.bryan@mayo.edu. Chicago – Among anesthesiology residents entering primary training from 1975 to 2009, 0.86 percent had a confirmed substance use disorder during training, with the incidence of this disorder increasing…

Diversity Initiatives Do Not Appear to Increase Representation of Minorities on Faculty of Medical Schools

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 3, 2013 Media Advisory: To contact James Guevara, M.D., M.P.H., call Dana Weidig at 267-426-6092 or email weidigd@email.chop.edu. Chicago – From 2000 to 2010, the presence of a minority faculty development program at U.S. medical schools was not associated with greater underrepresented minority faculty representation, recruitment, or…

Multifaceted Program to Improve Patient Continuity of Care in Hospitals Associated With Reduction in Medical Errors

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 3, 2013 Media Advisory: To contact Amy J. Starmer, M.D., M.P.H., call Meghan Weber at 617-919-3110 or email Meghan.Weber@childrens.harvard.edu. To contact editorial author Leora Horwitz, M.D., M.H.S., call Helen Dodson at 203-436-3984 or email helen.dodson@yale.edu. Chicago – Implementation of a multifaceted program to improve patient handoffs (change…

JAMA:11262013

Prevalence of Undiagnosed HIV Infection Low Among State Prison Entrants

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 26, 2013 Media Advisory: To contact David Alain Wohl, M.D., call Lisa Chensvold at 919-843-5719 or email lisa_chensvold@med.unc.edu. Chicago – An analysis indicates that the prevalence of undiagnosed human immunodeficiency virus (HIV) infection among state prison entrants in North Carolina was low, at 0.09 percent, according to…

Induced Hypothermia Does Not Improve Outcomes for Patients With Severe Bacterial Meningitis; May Be Harmful

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 26, 2013 Media Advisory: To contact Bruno Mourvillier, M.D., email bruno.mourvillier@bch.aphp.fr. Chicago – In a study of adults with severe bacterial meningitis, therapeutic hypothermia (reduction of body temperature) did not improve outcomes, and it may even have been harmful, according to a study appearing in the November…

Study Finds No Increased Risk of Retinal Detachment With Use of Certain Antibiotics

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 26, 2013 Media Advisory: To contact Bjorn Pasternak, M.D., Ph.D., email bjp@ssi.dk. To contact editorial author Allan S. Brett, M.D., call Jeff Stensland at 803-777-3686 or email stenslan@mailbox.sc.edu. Chicago – In contrast to findings of a recent study, researchers in Denmark did not find an association between…

Drug Improves Remission of Crohn Disease Among Children and Adolescents

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 26, 2013 Media Advisory: To contact Marzia Lazzerini, Ph.D., email lazzerini@burlo.trieste.it. Chicago – Among children and adolescents with Crohn disease not responding to treatment, use of the drug thalidomide resulted in improved clinical remission after 8 weeks of treatment compared with placebo, according to a study appearing…

Micronutrient Supplements Reduce Risk of HIV Disease Progression and Illness

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 26, 2013 Media Advisory: To contact Marianna K. Baum, Ph.D., call Maydel Santana-Bravo at 305-348-1555 or email santanam@fiu.edu. Chicago – Long-term (24-month) supplementation with multivitamins plus selenium for human immunodeficiency virus (HIV)-infected patients in Botswana in the early stages of disease who had not received antiretroviral therapy…

JAMA_OF:11182013

Addition of Dopamine or Nesiritide to Diuretic Therapy Does Not Improve Kidney Function in Patients With Heart Failure and Kidney Dysfunction

Embargoed for Early Release: 10:45 a.m CT Monday, November 18, 2013 Chicago – Horng H. Chen, M.B.B.Ch., of the Mayo Clinic, Rochester, Minn., and colleagues conducted a randomized trial to determine whether, as compared with placebo, the addition of low-doses of the drugs dopamine or nesiritide to diuretic therapy would enhance urine output and preserve…

JAMA_OF:11182013

Among Patients With Recent ACS, Use of Enzyme Inhibitor Does Not Reduce Risk of Cardiovascular Events; May Increase Risk of Heart Attack

Embargoed for Early Release: 3 p.m CT Monday, November 18, 2013 Chicago – Stephen J. Nicholls, M.B.B.S., Ph.D., of the South Australian Health and Medical Research Institute and University of Adelaide, Adelaide, Australia, and colleagues determined the effects of varespladib, a drug that inhibits the enzyme secretory phospholipase A2 on cardiovascular risk in patients with…

JAMA_OF:11182013

Therapy Using Stem Cells, Bone Marrow Cells, Appears Safe For Patients With Ischemic Cardiomyopathy

Embargoed for Early Release: 9:00 a.m CT Monday, November 18, 2013 Chicago – Alan W. Heldman, M.D., of the University of Miami Miller School of Medicine, and colleagues conducted a study to examine the safety of transendocardial stem cell injection (TESI) with autologous mesenchymal stem cells and bone marrow mononuclear cells in patients with ischemic…

Type of Cell Therapy Does Not Improve Walking Ability for Patients With Peripheral Artery Disease

Embargoed for Early Release: 9:00 a.m CT Monday, November 18, 2013 Chicago – Joseph Poole, M.D., Ph.D., of the Emory University School of Medicine, Atlanta, and colleagues studied whether therapy with granulocyte-macrophage colony stimulating factor (GM-CSF), an agent that functions as a white blood cell growth factor, would improve walking performance in patients with symptomatic…

Greater Density of Coronary Artery Calcium Associated With Lower Risk of Coronary Heart Disease, Cardiovascular Disease

Embargoed for Early Release: 9:00 a.m CT Monday, November 18, 2013 Chicago – Michael H. Criqui, M.D., M.P.H., of the University of California, San Diego, and colleagues determined the independent associations of coronary artery calcium (CAC) volume and CAC density with cardiovascular disease events. An increasing body of evidence suggests that greater calcium density in…

JAMA:11172013

JAMA_OF:11172013

JAMA_OF:11172013

Reducing Blood Pressure With Medications Immediately Following Ischemic Stroke Does Not Reduce Risk of Death, Disability

Embargoed for Early Release: 3:00 p.m CT Sunday, November 17, 2013 Chicago – Jiang He, M.D., Ph.D., of the Tulane University School of Public Health and Tropical Medicine, New Orleans, and colleagues examined whether moderate lowering of blood pressure within the first 48 hours after the onset of an acute ischemic stroke would reduce death…

Lowering of Body Temperature for Adults With Cardiac Arrest Prior to Hospital Arrival Does Not Improve Survival, Neurological Status

Embargoed for Early Release: 3:00 p.m CT Sunday, November 17, 2013 Chicago – Francis Kim, M.D., of Harborview Medical Center, Seattle, and colleagues evaluated whether early prehospital cooling (lowering body temperature) improved survival to hospital discharge and neurological outcome in cardiac arrest patients with or without ventricular fibrillation (VF). Cardiac arrest can cause brain injury…

Use of Device For Chest Compressions Compared to Manual CPR Does Not Improve Short-term Survival Following Cardiac Arrest

Embargoed for Early Release: 1:00 p.m CT Sunday, November 17, 2013 Chicago – Sten Rubertsson, M.D., Ph.D., of Uppsala University, Sweden and colleagues assessed whether cardiopulmonary resuscitation (CPR) in which chest compressions are delivered with a mechanical device would result in superior 4-hour survival in patients with out-of-hospital cardiac arrest compared to CPR with manual…

Rate of Aortic Valve Replacement For Elderly Patients Has Increased; Outcomes Improved

Embargoed for Early Release: 11:00 a.m CT Sunday, November 17, 2013 Chicago – Jose Augusto Barreto-Filho, M.D., Ph.D., of the Federal University of Sergipe and the Clinica e Hospital Sao Lucas, Sergipe, Brazil, and colleagues assessed procedure rates and outcomes of surgical aortic valve replacement (AVR) among 82,755,924 Medicare fee-for-service beneficiaries between 1999 and 2011….

Study Examines Effectiveness, Safety of Transcatheter Aortic Valve Replacement in U.S.

Embargoed for Early Release: 11:00 a.m CT Sunday, November 17, 2013 Chicago – Michael J. Mack, M.D., of the Baylor Health Care System, Plano, Texas, and colleagues describe the experience in the U.S. with transcatheter aortic valve replacement (TAVR), including patient selection, procedural details, and in-hospital and 30-day outcomes following TAVR, a less invasive procedure…

Method to Estimate LDL-C May Provide More Accurate Risk Classification

Embargoed for Early Release: 11:00 a.m CT Sunday, November 17, 2013 Chicago – Seth S. Martin, M.D., of the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, and colleagues developed a method for estimating low-density lipoprotein cholesterol (LDL-C) levels that is more accurate than the standard measure. Low-density lipoprotein cholesterol is the…

Weight Reduction Decreases Atrial Fibrillation and Symptom Severity

Embargoed for Early Release: 11:00 a.m CT Sunday, November 17, 2013 Chicago – Hany S. Abed, B.Pharm., M.B.B.S., of the University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia and colleagues evaluated the effect of a structured weight reduction program on atrial fibrillation symptoms. “Atrial fibrillation has been described as the epidemic of the new…

JAMA_OF:11092013

Use of Calcium-Channel Blocker and Antibiotic Associated With Small Increased Risk of Kidney Injury

EMBARGOED FOR EARLY RELEASE: 9 A.M. (CT) SATURDAY, NOVEMBER 9, 2013 Media Advisory: To contact corresponding author Amit X. Garg, M.D., Ph.D., call Julia Capaldi at 519-685-8500, ext. 75616, or email julia.capaldi@lawsonresearch.com. Chicago – Among older adults taking a calcium-channel blocker, simultaneous use of the antibiotic clarithromycin, compared with azithromycin, was associated with a small…

JAMA:11122013

Going to the Moon in Health Care

EMBARGOED FOR EARLY RELEASE: 9:30 A.M. (ET) TUESDAY, NOVEMBER 12, 2013 Media Advisory: To contact Ezekiel J. Emanuel, M.D., Ph.D., call Katie Delach at 215-349-5964 or email Katie.Delach@uphs.upenn.edu. Washington, D.C. – The U.S. health care system needs a new, audacious goal: limit health care expenditure growth to the growth of national economy. “That is, by…

Reliable and Sustainable Comprehensive Care for Frail Elderly People

EMBARGOED FOR EARLY RELEASE: 9:30 A.M. (ET) TUESDAY, NOVEMBER 12, 2013 Media Advisory: To contact Joanne Lynn, M.D., M.A., M.S., call Ken Schwartz at 571-733-5709 or email Ken.schwartz@altarum.org. Washington, D.C. – “The United States needs arrangements that allow elderly people to live with confidence, comfort, and meaningfulness at a cost that families can afford and…

Analysis of Health Care in U.S. Indicates That Improvement in Outcomes Has Slowed

EMBARGOED FOR EARLY RELEASE: 9:30 A.M. (ET) TUESDAY, NOVEMBER 12, 2013 Media Advisory: To contact Hamilton Moses III, M.D., call Stephanie Desmon at 410-955-8665 or email sdesmon1@jhmi.edu. Washington, D.C. – An examination of health care in the U.S. finds that despite the extraordinary economic success of many of its participants, the health care system has…

JAMA_OF:11042013

Little Difference Found Between Self-Reported and Measured Weights Following Bariatric Surgery

EMBARGOED FOR EARLY RELEASE: 10 A.M. (CT) MONDAY, NOVEMBER 4, 2013 Media Advisory: To contact Nicholas J. Christian, Ph.D., email Allison Hydzik (HydzikAM@upmc.edu) or Cyndy McGrath (McGrathC3@upmc.edu) or call 412-647-9975. In an analysis that included nearly 1,000 patients, self-reported weights following bariatric surgery were close to measured weights, suggesting that self-reported weights used in studies…

Study Finds Substantial Weight Loss For Severely Obese Individuals Three Years After Bariatric Surgery

EMBARGOED FOR EARLY RELEASE: 10:00 A.M. (CT) MONDAY, NOVEMBER 4, 2013 Media Advisory: To contact Anita P. Courcoulas, M.D., M.P.H., call Andréa Stanford at 412-647-6190 or email Stanfordac@upmc.edu. In 3-year follow-up after bariatric surgery, substantial weight loss was observed among individuals who were severely obese, with most of the change occurring during the first year;…

JAMA:11052013

Autoantibodies Found in Blood Years Before Symptom Onset of Autoimmune Disease

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 5, 2013 Media Advisory: To contact corresponding author Gunnel Henriksson, M.D., Ph.D., email Gunnel.Henriksson@med.lu.se. Autoantibodies are present many years before symptom onset in patients with primary Sjögren syndrome, an autoimmune disease, according to a Research Letter published in the November 6 issue of JAMA. Primary Sjögren syndrome…

Intervention Increases Clinician Recommendations For Antidepressant Drugs, Mental Health Referral, But Does Not Improve Depression Symptoms

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 5, 2013 Media Advisory: To contact Richard L. Kravitz, M.D., M.S.P.H., call Charles Casey at 916-734-9048 or email  charles.casey@ucdmc.ucdavis.edu. Chicago — Among depressed patients evaluated in a primary care setting, use of an interactive multimedia computer program immediately prior to a primary care visit resulted in the…

Findings Do Not Indicate Association Between Potentially Sleep-Deficient Surgeons and Subsequent Surgical Complications

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 5, 2013 Media Advisory: To contact Christopher Vinden, M.D., call Julia Capaldi at 519-685-8500, ext. 75616 or email Julia.Capaldi@LawsonResearch.Com. To contact editorial co-author Michael J. Zinner, M.D., call Tom Langford at 617-525-6375 or email tlangford@partners.org. Chicago — Surgeons who had operated the night before an elective daytime…

Testosterone Therapy Following Coronary Angiography Associated With Increased Risk Of Adverse Outcomes

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 5, 2013 Media Advisory: To contact corresponding author P. Michael Ho, M.D., Ph.D., call Mark Couch at 303-724-5377 or email mark.couch@ucdenver.edu. To contact editorial author Anne R. Cappola, M.D., Sc.M., call Kim Menard at 215-662-6183 or email kim.menard@uphs.upenn.edu. Chicago — Among a group of men who underwent…

JAMA_OF:10312013

Shorter-Term Dual Antiplatelet Therapy After Receiving Drug-Releasing Stent Does Not Worsen Outcomes

EMBARGOED FOR EARLY RELEASE: 11:30 A.M. (CT) THURSDAY, OCTOBER 31, 2013 Media Advisory: To contact Fausto Feres, M.D., Ph.D., email fferes@lee.dante.br.   Short-term (3 months) vs. long-term (12 months) dual anti­platelet therapy did not result in poorer outcomes on certain measures (death, heart attack, stroke, and bleeding) for patients with coronary artery disease or low-risk…

JAMA:10222013

Intranasal Application of Hormone Appears To Enhance Placebo Response

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 22, 2013 Media Advisory: To contact corresponding author Ulrike Bingel, M.D., Ph.D., email ulrike.bingel@uk-essen.de.   The hormone oxytocin may mediate processes such as empathy, trust, and social learning. These are key elements of the patient-physician relationship, which is an important mediator of placebo responses, according to background…

Brief Risk-Reduction Counseling At Time of HIV Testing Does Not Result in Reduction in Rate of STIs

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 22, 2013 Media Advisory: To contact Lisa R. Metsch, Ph.D., call Stephanie Berger at 212-305-4372 or email sb2247@columbia.edu. To contact editorial co-author Jason S. Haukoos, M.D., M.Sc., call Jenny Bertrand at 303-520-9591 or email Jennifer.Bertrand@dhha.org.   Brief risk-reduction counseling at the time of a rapid human immunodeficiency…

Flu Vaccine Associated With Lower Risk of Cardiovascular Events

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 22, 2013 Media Advisory: To contact Jacob A. Udell, M.D., M.P.H., F.R.C.P.C., call Nicole Bodnar at 416-978-5811 or email Nicole.Bodnar@utoronto.ca. To contact editorial author Kathleen M. Neuzil, M.D., M.P.H., call Monica Graham at 206-302-6072 or email mgraham@path.org.   Receiving an influenza vaccination was associated with a lower…

JAMA_OF:10172013

Increase Seen in Donor Eggs For In Vitro Fertilization, With Improved Outcomes

EMBARGOED FOR EARLY RELEASE: 6:00 A.M. (CT) THURSDAY, OCTOBER 17, 2013 Media Advisory: To contact Jennifer F. Kawwass, M.D., call Janet Christenbury at 404-727-8599 or email Jmchris@emory.edu. To contact editorial author Evan R. Myers, M.D., M.P.H., call Rachel Harrison at 919-419-5069 or email rachel.harrison@duke.edu. Between 2000 and 2010 in the United States the number of…

JAMA:10152013

Medication Taken for Nausea During Pregnancy Not Associated With Increased Risk of Major Malformations, Stillbirth

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 15, 2013 Media Advisory: To contact Bjorn Pasternak, M.D., email bjp@ssi.dk. In an analysis that included more than 40,000 women exposed to the nausea medication metoclopramide in pregnancy, use of this drug was not associated with significantly increased risk of major congenital malformations overall, spontaneous abortion, and…