Inhibiting Inflammatory Enzyme After Heart Attack Does Not Reduce Risk of Subsequent Event

EMBARGOED FOR EARLY RELEASE: 2 A.M. (CT) SUNDAY, AUGUST 31, 2014 Media Advisory: To contact Michelle L. O’Donoghue, M.D., M.P.H., call Jessica Maki at 617-525-6373 or email jmaki3@partners.org. Inhibiting Inflammatory Enzyme After Heart Attack Does Not Reduce Risk of Subsequent Event In patients who experienced an acute coronary syndrome (ACS) event (such as heart attack…

Medication Shows Mixed Results in Reducing Complications From Cardiac Surgery

EMBARGOED FOR EARLY RELEASE: 6 A.M. (CT) SATURDAY, AUGUST 30, 2014 Media Advisory: To contact Massimo Imazio, M.D., email massimo_imazio@yahoo.it. Medication Shows Mixed Results in Reducing Complications From Cardiac Surgery Administration of colchicine, a plant-based medication commonly used to treat gout, before and after cardiac surgery showed mixed results in reducing potential complications from this…

JAMA:08262014

Study Questions Generalizability of Findings of Cardiovascular Trials for Heart Attack Patients

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 26, 2014 Media Advisory: To contact Jacob A. Udell, M.D., M.P.H., call Heidi Singer at 416-978-5811 or email Heidi.Singer@utoronto.ca. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.6217. Study Questions Generalizability…

EPO May Help Reduce Risk of Brain Abnormalities in Preterm Infants

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 26, 2014 Media Advisory: To contact corresponding author Petra Susan Huppi, M.D., email petra.huppi@hcuge.ch. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.9645. EPO May Help Reduce Risk of Brain Abnormalities…

Collaborative Care Intervention Improves Depression Among Teens

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 26, 2014 Media Advisory: To contact Laura P. Richardson, M.D., M.P.H., email Rose Ibarra at rose.ibarra@seattlechildrens.org. To contact editorial co-author Mark A. Riddle, M.D., email Ekaterina Pesheva at epeshev1@jhmi.edu. To place an electronic embedded link to this study and editorial in your story This link to the…

Hypertension Self-Management Program Helps Reduce Blood Pressure For High-Risk Patients

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 26, 2014 Media Advisory: To contact Richard J. McManus, F.R.C.G.P., email richard.mcmanus@phc.ox.ac.uk. To contact editorial co-author Peter M. Nilsson, M.D., Ph.D., email Peter.Nilsson@med.lu.se. To place an electronic embedded link to this study and editorial in your story This link to the study will be live at the…

JAMA:08192014

Prevalence of Herpes Simplex Virus Type 2 Decreases Among Pregnant Women in the Pacific Northwest

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 19, 2014 Media Advisory: To contact Shani Delaney, M.D., email Susan Gregg at sghanson@uw.edu. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.9237. Prevalence of Herpes Simplex Virus Type 2 Decreases…

Study Examines Incidence, Survival Rate of Severe Immunodeficiency Disorder in Newborns

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 19, 2014 Media Advisory: To contact corresponding author Jennifer M. Puck, M.D., email Juliana Bunim at juliana.bunim@ucsf.edu. To contact editorial author Neil A. Holtzman, M.D., M.P.H., call Ekaterina Pesheva at 410-502-9433 or email epeshev1@jhmi.edu. To place an electronic embedded link to this study and editorial in your…

Findings Suggest Over-Reliance on Pulse Oximetry for Determining Whether Children With Respiratory Infection Should Be Hospitalized

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 19, 2014 Media Advisory: To contact Suzanne Schuh, M.D., F.R.C.P.C., call Matet Nebres at 416-813-6380 or email matet.nebres@sickkids.ca. To contact editorial co-author Robert Vinci, M.D., email Jenny Eriksen Leary at Jenny.Eriksen@bmc.org. To place an electronic embedded link to this study and editorial in your story This link…

Intervention Helps Smokers Quit Following Hospital Stay

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 19, 2014 Media Advisory: To contact Nancy A. Rigotti, M.D., call Terri Ogan at 617-726-0954 or email togan@partners.org. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.9237. Intervention Helps Smokers Quit…

JAMA:08122014

Approach Used to Conduct Meta-Analyses May Affect Outcomes

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 12, 2014 Media Advisory: To contact Agnes Dechartres, M.D., Ph.D., email agnes.dechartres@htd.aphp.fr. To contact editorial co-author Robert M. Golub, M.D., call Jim Michalski at 312-464-5785 or email jim.michalski@jamanetwork.org. To place an electronic embedded link to this study in your story This link for the study will be…

Delay in Correcting Irregular Cardiac Rhythm From Atrial Fibrillation Associated With Increased Risk of Complications

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 12, 2014 Media Advisory: To contact corresponding author K. E. Juhani Airaksinen, M.D., Ph.D., email juhani.airaksinen@tyks.fi. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.3824. Delay in Correcting Irregular Cardiac Rhythm…

Experiencing Atrial Fibrillation While Hospitalized For Surgery Associated With Increased Long-Term Risk of Stroke

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 12, 2014 Media Advisory: To contact corresponding author Hooman Kamel, M.D., call Ashley Paskalis at 646-317-7378 or email asp2011@med.cornell.edu. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.9143. Experiencing Atrial Fibrillation…

Flexible Sigmoidoscopy Screening Reduces Colorectal Cancer Incidence, Rate of Death

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 12, 2014 Media Advisory: To contact Øyvind Holme, M.D., email oyvind.holme@sshf.no. To contact editorial author Allan S. Brett, M.D., email Matt Splett at matt.splett@uscmed.sc.edu. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo…

JAMA:08052014

Study Identifies Genetic Variants Associated with Severe Skin Reactions to Commonly Used Antiepileptic Drug

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 5, 2014 Media Advisory: To contact corresponding author Wen-Hung Chung, M.D., Ph.D., email chung1@cgmh.org.tw; to contact Shuen-Iu Hung, Ph.D., email sihung@ym.edu.tw. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.7859. Study…

Using Long-Detection Interval for ICDs Associated With Reduction in Hospitalizations, Costs

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 5, 2014 Media Advisory: To contact corresponding author Maurizio Gasparini, M.D., email maurizio.gasparini@humanitas.it. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.4783. Using Long-Detection Interval for ICDs Associated With Reduction in…

Enriching Feeding Tube Nutrition With Immune-Modulating Nutrients Does Not Reduce Risk of Infection Among ICU Patients

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 5, 2014 Media Advisory: To contact Arthur R. H. van Zanten, M.D., Ph.D., email zantena@zgv.nl. To contact editorial author Todd W. Rice, M.D., M.Sc., email Craig Boerner at craig.boerner@Vanderbilt.Edu. To place an electronic embedded link to this study in your story This link for the study will…

Studies Find Brief Interventions Ineffective for Reducing Unhealthy, Problem Drug Use

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 5, 2014 Media Advisory: To contact Peter Roy-Byrne, M.D., call 206-386-3103. To contact Richard Saitz, M.D., email Lisa Chedekel at chedekel@bu.edu. To contact editorial co-author Ralph Hingson, Sc.D., M.P.H., call the NIAAA Press Office at 301-443-3860 or email NIAAAPressOffice@mail.nih.gov. To place an electronic embedded link to these…

JAMA_OF:07222014

Study Examines Presence of Uterine Cancers Among Women At the Time of Hysterectomy Using Morcellation

EMBARGOED FOR RELEASE: 10 A.M. (CT) TUESDAY, JULY 22, 2014 Media Advisory: To contact Jason D. Wright, M.D., email Lucky Tran at cumcnews@columbia.edu. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.9005 Among women undergoing a minimally invasive hysterectomy…

JAMA:07192014

JAMA_OF:07202014

Providing Economic Incentive Results in Modest Increase in Medical Male Circumcision Performed to Help Reduce Risk of HIV

EMBARGOED FOR EARLY RELEASE: 10 P.M. (CT) SUNDAY, JULY 20, 2014 Media Advisory: To contact Harsha Thirumurthy, Ph.D., call David Pesci at 919-962-2600 or email dpesci@email.unc.edu. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.9087 Among uncircumcised men in…

Growth Hormone Analog Shows Potential For Reducing Risk of Fatty Liver Disease in HIV-Infected Patients

EMBARGOED FOR EARLY RELEASE: 10 A.M. (CT) SATURDAY, JULY 19, 2014 Media Advisory: To contact corresponding author Steven K. Grinspoon, M.D., call Cassandra Aviles at 617-724-6433 or email cmaviles@partners.org. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.8334 In…

Study Examines Effect on Pregnancy of Receiving Antiretroviral Therapy for Prevention of HIV

EMBARGOED FOR EARLY RELEASE: 10 A.M. (CT) SATURDAY, JULY 19, 2014 Media Advisory: To contact corresponding author Jared M. Baeten, M.D., Ph.D., call Bobbi Nodell at 206-543-7129 or email bnodell@uw.edu. To contact editorial co-author David A. Cooper, M.D., D.Sc., email dcooper@kirby.unsw.edu.au. To place an electronic embedded link to this study in your story This link…

Offering Option of Initial HIV Care at Home Increases Use of Antiretroviral Therapy

EMBARGOED FOR EARLY RELEASE: 10 A.M. (CT) SATURDAY, JULY 19, 2014 Media Advisory: To contact Peter MacPherson, Ph.D., email petermacp@gmail.com. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.6493 Among adults in the African country of Malawi offered HIV…

Combination Treatment for Hepatitis C Associated With Favorable Response Among Patients With HIV

EMBARGOED FOR EARLY RELEASE: 10 A.M. (CT) SATURDAY, JULY 19, 2014 Media Advisory: To contact Mark S. Sulkowski, M.D., call Lauren Nelson at 410-955-8725 or email lnelso35@jhmi.edu. To contact editorial co-author Michael S. Saag, M.D., email Nicole Wyatt at nwyatt@uab.edu. To place an electronic embedded link to this study in your story This link for…

Overall HIV Diagnosis Rate Decreases Significantly in U.S. Over a Decade, Although Increase Seen for Certain Groups

EMBARGOED FOR EARLY RELEASE: 10 A.M. (CT) SATURDAY, JULY 19, 2014 Media Advisory: To contact Anna Satcher Johnson, M.P.H., call the CDC’s news media line at 404-639-8895 or email NCHHSTPMediaTeam@cdc.gov. To place an electronic embedded link to this study in your story This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.8534…

JAMA:07152014

Common Treatment of Certain Autoimmune Disease Does Not Appear Effective

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 15, 2014 Media Advisory: To contact corresponding author Jacques-Eric Gottenberg, M.D., Ph.D., email jacques-eric.gottenberg@chru-strasbourg.fr; to contact Xavier Mariette, M.D., Ph.D., email xavier.mariette@bct.aphp.fr. To place an electronic embedded link to this study in your story  This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.7682…

Physicians Have Higher Rate of Organ Donation Registration than General Public

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 15, 2014 Media Advisory: To contact co-author Amit X. Garg, M.D., Ph.D., email Julia Capaldi at Julia.Capaldi@LawsonResearch.com. To place an electronic embedded link to this study in your story  This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.2934 A study that included about…

History of Stroke Linked with Increased Risk of Adverse Outcomes after Non-Cardiac Surgery

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 15, 2014 Media Advisory: To contact Mads E. Jørgensen, M.B., email mads.emil.joergensen@regionh.dk. To place an electronic embedded link to this study in your story  This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.8165 In an analysis that included more than 480,000 patients who…

Telecare Intervention Improves Chronic Pain

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 15, 2014 Media Advisory: To contact Kurt Kroenke, M.D., email Lisa Welch at llwelch@regenstrief.org. To contact editorial co-author Gary E. Rosenthal, M.D., email Tom Moore at thomas-moore@uiowa.edu. To place an electronic embedded link to this study in your story  This link for the study will be live…

Study Finds Decrease in Incidence of Stroke, Subsequent Death

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 15, 2014 Media Advisory: To contact corresponding author Josef Coresh, M.D., Ph.D., call Stephanie Desmon at 410-955-7619 or email sdesmon1@jhu.edu. To contact editorial co-author Ralph L. Sacco, M.D., call Lisa Worley at 305-243-5184 or email lworley2@med.miami.edu. To place an electronic embedded link to this study in your…

JAMA:07082014

Study Estimates Rate of Survival Following Minimally Invasive Repair of Failed Bioprosthetic Aortic Valves

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 8, 2014 Media Advisory: To contact Danny Dvir, M.D., call Dave Lefebvre at 604-682-2344, ext. 66987; or email Dlefebvre@providencehealth.bc.ca. To place an electronic embedded link to this study in your story  This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.7246 In an analysis…

Removing Gall Bladder For Suspected Common Duct Stone Shows Benefit

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 8, 2014 Media Advisory: To contact Pouya Iranmanesh, M.D., email pouya.iranmanesh@hcuge.ch. To place an electronic embedded link to this study in your story  This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.7587   Among patients with possible common duct stones, removal of the…

Study Does Not Find Increased Risk of Blood Clot Following HPV Vaccination

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 8, 2014 Media Advisory: To contact Nikolai Madrid Scheller, M.B., email nmscheller@gmail.com. To place an electronic embedded link to this study in your story  This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.2198 Although some data has suggested a potential association between receipt…

Antibiotics After Gall Bladder Surgery Do Not Appear to Reduce Risk of Infection

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 8, 2014 Media Advisory: To contact Jean Marc Regimbeau, M.D., Ph.D., email regimbeau.jean-marc@chu-amiens.fr. To contact editorial author Joseph S. Solomkin, M.D., call Katy Cosse at 513-558-0207 or email kathryn.cosse@uc.edu. To place an electronic embedded link to this study in your story  This link for the study will…

Varenicline Combined With Nicotine Patch Improves Smoking Cessation Rates

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 8, 2014 Media Advisory: To contact Coenraad F. N. Koegelenberg, M.D., Ph.D., email coeniefn@sun.ac.za. To place an electronic embedded link to this study in your story  This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.7195.   Combining the smoking cessation medication varenicline with…

JAMA:07012014

Whole-Exome Sequencing Helpful in Identifying Gene Mutations Linked to Certain Nervous System Diseases

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 1, 2014 Media Advisory: To contact corresponding author Patrick F. Chinnery, Ph.D., F.R.C.P., F.Med.Sci., email patrick.chinnery@ncl.ac.uk. To place an electronic embedded link to this study in your story  This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.7184   Use of exome sequencing improved…

Among Patients with TBI, Maintaining Higher Hemoglobin Concentration or Receiving Hormone EPO Does Not Improve Neurological Outcomes

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 1, 2014 Media Advisory: To contact Claudia S. Robertson, M.D., call Graciela Gutierrez at 713-798-4710 or email ggutierr@bcm.edu. To place an electronic embedded link to this study in your story  This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.6490 In patients with a…

Drug Everolimus Does Not Improve Overall Survival in Patients with Advanced Liver Cancer

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 1, 2014 Media Advisory: To contact Andrew X. Zhu, M.D., Ph.D., call Katie Marquedant at 617-726-0337 or email KMarquedant@mgh.harvard.edu. To place an electronic embedded link to this study in your story  This link for the study will be live at the embargo time: http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.7189   Despite strong…

Bone Marrow Transplantation Shows Potential for Treating Adults with Severe Sickle Cell Disease

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 1, 2014 Media Advisory: To contact Matthew M. Hsieh, M.D., or corresponding author John F. Tisdale, M.D., call Krysten Carrera at 301-435-8112 or email krysten.carrera@nih.gov. To contact editorial co-author John F. DiPersio, M.D., Ph.D., call Jim Goodwin at 314-286-0166 or email jgoodwin@wustl.edu. To place an electronic embedded…

JAMA06242014

Stem Cell Transplantation For Severe Sclerosis Associated With Improved Long-term Survival

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 24, 2014 Media Advisory: To contact corresponding author Jacob M. van Laar, M.D., Ph.D., email j.m.vanlaar@umcutrecht.nl; or Dominique Farge, M.D., Ph.D., email dominique.farge-bancel@sls.aphp.fr. To contact editorial co-author Dinesh Khanna, M.D., M.Sc., call Beata Mostafavi at 734-764-2220 or email bmostafa@med.umich.edu. Among patients with a severe, life-threatening type of…

Use of Regional Anesthesia During Hip Fracture Surgery Not Associated With Lower Risk of Death

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 24, 2014 Media Advisory: To contact Mark D. Neuman, M.D., M.Sc., call Lee-Ann Donegan at 215-349-5660 or email Leeann.Donegan@uphs.upenn.edu. Among more than 56,000 adults undergoing hip repair between 2004 and 2011, the use of regional anesthesia compared with general anesthesia was not associated with a lower risk…

Addition of 3-D Imaging Technique to Mammography Increases Breast Cancer Detection Rate

Media Advisory: To contact Sarah M. Friedewald, M.D., call Mickey Ramirez at 847-723-5637 or email Mickey.Ramirez@advocatehealth.com. To contact editorial co-author Etta D. Pisano, M.D., call Deborah Reynolds at 843-324-0984 or email reynodh@musc.edu.   The addition of tomosynthesis, a 3-dimensional breast imaging technique, to digital mammography in more than 170,000 examinations was associated with a decrease…

JAMA:06172014

Compared to Chemotherapy, Treatment with Selumetinib not Associated with Improved Long Term Survival for Patients with an Uncommon Eye Cancer

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 17, 2014 Media Advisory: To contact Richard D. Carvajal, M.D., call Courtney DeNicola Nowak at 212-639-3573 or email denicolc@mskcc.org.   In patients with advanced uveal melanoma, treatment with the agent selumetinib, compared with chemotherapy, resulted in an improved cancer progression-free survival time and tumor response rate, but…

Use of Tumor Necrosis Factor Inhibitors for Treatment of Inflammatory Bowel Disease Not Associated With Increased Risk of Cancer

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 17, 2014 Media Advisory: To contact Nynne Nyboe Andersen, M.D., email nyna@ssi.dk.   In a study that included more than 56,000 patients with inflammatory bowel disease, use of a popular class of medications known as tumor necrosis factor alpha antagonists was not associated with an increased risk…

Survey Suggests That Self-Reported Health of Young Adults Has Improved Since Health Reform Measure of 2010

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 17, 2014 Media Advisory: To contact Kao-Ping Chua, M.D., call Todd Datz at 617-432-8413 or email tdatz@hsph.harvard.edu.   Findings of a large survey indicate that since 2010, when young adults could be covered under their parents’ health insurance plans until age 26, self-reported health among this group…

Analysis Finds Mixed Results for Use of Thrombolytic Therapy for Blood Clot in Lungs

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 17, 2014 Media Advisory: To contact corresponding author Jay Giri, M.D., M.P.H., call Lee-Ann Donegan at 215-349-5660 or email Leeann.donegan@uphs.upenn.edu. To contact editorial author Joshua A. Beckman, M.D., call Jessica Maki at 617-525-6373 or email jmaki3@partners.org.   In an analysis that included data from 16 trials performed…

JAMA:06102014

Hydrolyzed Infant Formula Does Not Reduce Diabetes-Associated Autoantibodies in At-Risk Infants

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 10, 2014 Media Advisory: To contact Mikael Knip, M.D., D.M.Sc., email mikael.knip@helsinki.fi. Among infants at risk for type 1 diabetes, the use of a hydrolyzed formula (one that does not contain intact proteins) compared with a conventional formula did not reduce the incidence of diabetes-associated autoantibodies after…

Gene Variant Associated With Type 2 Diabetes in Latino Population

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 10, 2014 Media Advisory: To contact corresponding author Jose C. Florez, M.D., Ph.D., call Haley Bridger at 617-714-7968 or email hbridger@broadinstitute.org. A genetic analysis of DNA samples of approximately 3,700 Mexican and U.S. Latino individuals identified a gene variant that was associated with a 5-fold increase in…

Large Increase Seen in Insulin Use, Out-of-Pocket Costs for Type 2 Diabetes

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 10, 2014 Media Advisory: To contact Kasia J. Lipska, M.D., M.H.S., call Helen Dodson at 203-436-3984 or email helen.dodson@yale.edu. Largely attributable to the widespread adoption of insulin analogs, use of insulin among patients with type 2 diabetes increased from 10 percent in 2000 to 15 percent in…

For Patients Receiving Metformin to Treat Diabetes, Addition of Insulin Associated With Increased Risk of Death

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 10, 2014 Media Advisory: To contact Christianne L. Roumie, M.D., M.P.H., call Craig Boerner at 615-322-4747 or email craig.boerner@vanderbilt.edu. To contact editorial author Monika M. Safford, M.D., call Bob Shepard at 205-934-8934 or email bshep@uab.edu. Among patients with diabetes who were receiving metformin, the addition of insulin…

Long-Term Follow-up After Bariatric Surgery Shows Greater Rate of Diabetes Remission

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 10, 2014 Media Advisory: To contact Lars Sjostrom, M.D., Ph.D., email lars.v.sjostrom@medfak.gu.se.   In a study that included long-term follow-up of obese patients with type 2 diabetes, bariatric surgery was associated with more frequent diabetes remission and fewer complications than patients who received usual care, according to…

JAMA_OF:06032014

Findings Show Benefit of Changing Measure of Kidney Disease Progression

EMBARGOED FOR EARLY RELEASE: 5:45 A.M. (CT) TUESDAY, JUNE 3, 2014 Media Advisory: To contact Josef Coresh, M.D., Ph.D., call Barbara Benham at 410-614-6029 or email bbenham1@jhu.edu. Developing therapies for kidney disease can be made faster by adopting a new, more sensitive definition of kidney disease progression, according to a study published by JAMA. The…

JAMA:O6032014

Study Finds High Risk of Recurrence of Two Life-Threatening Adverse Drug Reactions That Affect the Skin

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 3, 2014 Media Advisory: To contact Yaron Finkelstein, M.D., call Suzanne Gold at 416-813-7654, ext. 202059, or email suzanne.gold@sickkids.ca. Individuals who are hospitalized for the skin conditions of Stevens-Johnson syndrome and toxic epidermal necrolysis appear to have a high risk of recurrence, according to a study in…

For Older Adults With Pneumonia, Treatment Including Azithromycin Associated With Lower Risk of Death, Small Increased Risk of Heart Attack

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 3, 2014 Media Advisory: To contact Eric M. Mortensen, M.D., M.Sc., call Penny Kerby at 214-857-1155 or email Penny.Kerby@va.gov. In a study that included nearly 65,000 older patients hospitalized with pneumonia, treatment that included azithromycin compared with other antibiotics was associated with a significantly lower risk of…

Preventive Placement of ICDs in Patients With Less Severe Heart Failure Associated With Improved Survival

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 3, 2014 Media Advisory: To contact Sana M. Al-Khatib, M.D., M.H.S., call Rachel Harrison at 919-419-5069 or email rachel.harrison@duke.edu. An examination of the benefit of preventive placement of implantable cardioverter-defibrillators (ICDs) in patients with a less severe level of heart failure, a group not well represented in…

JAMA:05272014

JAMA_OF:05272014

Study Examines Variation in Cardiology Practice Guidelines Over Time

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 27, 2014 Media Advisory: To contact Mark D. Neuman, M.D., M.Sc., email neumanm@mail.med.upenn.edu or call 215-760-7471; or email Jessica Mikulski at Jessica.Mikulski@uphs.upenn.edu or call 215-796-4829. To contact editorial author Paul G. Shekelle, M.D., Ph.D., call Warren Robak at 310-451-6913 or email robak@rand.org. An analysis of more than…

Endoscopic Procedure Does Not Reduce Disability Due to Pain Following Gallbladder Removal

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 27, 2014 Media Advisory: To contact Peter B. Cotton, M.D., F.R.C.P., F.R.C.S., call Heather Woolwine at 843-792-7669 or email woolwinh@musc.edu. In certain patients with abdominal pain after gallbladder removal (cholecystectomy), undergoing an endoscopic procedure involving the bile and pancreatic ducts did not result in fewer days with…

Moderate-Intensity Physical Activity Program For Older Adults Reduces Mobility Problems

EMBARGOED FOR EARLY RELEASE: 1 P.M. (ET) TUESDAY, MAY 27, 2014 Media Advisory: To contact Marco Pahor, M.D., call Morgan Sherburne at 352-273-6160 or email msherburne@ufl.edu. Among older adults at risk of disability, participation in a structured moderate-intensity physical activity program, compared with a health education intervention, significantly reduced the risk of major mobility disability…

JAMA:05202014

Comparison of Newer and Older Antipsychotic Medications For Schizophrenia Finds Similar Clinical Outcomes

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 20, 2014 Media Advisory: To contact corresponding author T. Scott Stroup, M.D., M.P.H., call Dacia Morris at 646-774-8724 or email morrisd@nyspi.columbia.edu. To contact editorial author Donald C. Goff, M.D., call Lorinda Klein at 212-404-3533 or email Lorindaann.klein@nyumc.org.   Among adults with schizophrenia or schizoaffective disorder, treatment with…

Research Identifies Genetic Alterations in Lung Cancers That Help Select Treatment; May Improve Survival

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 20, 2014 Media Advisory: To contact Mark G. Kris, M.D., call Melissa Morgenweck at 646-227-3633 or email morgenwm@mskcc.org. To contact editorial co-author Boris Pasche, M.D., Ph.D., call Marguerite Beck at 336-716-2415 or email marbeck@wakehealth.edu.   Multiplexed testing of lung cancer tumors identified genetic alterations that were helpful…

Antibiotics Continue to Be Prescribed at High Rate for Bronchitis, Contrary to Recommended Guidelines

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 20, 2014 Media Advisory: To contact Jeffrey A. Linder, M.D., M.P.H., call Jessica Maki at 617-525-6373 or email jmaki3@partners.org. Despite clear evidence of ineffectiveness, guidelines and more than 15 years of educational efforts stating that the antibiotic prescribing rate for acute bronchitis should be zero, the rate…

Physical Therapy for Hip Osteoarthritis Does Not Appear to Provide Greater Improvement for Pain, Function

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 20, 2014 Media Advisory: To contact Kim L. Bennell, Ph.D., email k.bennell@unimelb.edu.au.   Among adults with painful hip osteoarthritis, physical therapy did not result in greater improvement in pain or function compared with a placebo treatment, but was associated with relatively frequent but mild adverse effects, raising…

JAMA_OF:05192014

JAMA_OF:05182014

Study Examines Effect of Intervention to Increase Blood Flow During and After Major Surgery

EMBARGOED FOR EARLY RELEASE: 4 P.M. (CT) MONDAY, MAY 19, 2014 Media Advisory: To contact Rupert M. Pearse, M.D., email r.pearse@qmul.ac.uk. To contact editorial author Elliott Bennett-Guerrero, M.D., call Sarah Avery at 919-660-1306 or email sarah.avery@duke.edu.   In a study that included high-risk patients undergoing major gastrointestinal surgery, the use of a cardiac-output guided intervention…

For Pregnant Women Who Smoke, Vitamin C Supplementation Results in Improved Lung Function of Newborn

EMBARGOED FOR EARLY RELEASE: 4 P.M. (CT) SUNDAY, MAY 18, 2014 Media Advisory: To contact Cindy T. McEvoy, M.D., M.C.R., call Tamara Hargens-Bradley at 503-494-8231 or email hargenst@ohsu.edu. To contact editorial author Graham L. Hall, Ph.D., email graham.hall@telethonkids.org.au. Supplemental vitamin C taken by pregnant smokers improved measures of lung function for newborns and decreased the…

Sepsis Involved in High Percentage of Hospital Deaths

EMBARGOED FOR EARLY RELEASE: 4 P.M. (CT) SUNDAY, MAY 18, 2014 Media Advisory: To contact Vincent Liu, M.D., M.S., call Ann Wallace at 510-891-3653 or email ann.m.wallace@kp.org. An analysis that included approximately 7 million hospitalizations finds that sepsis contributed to 1 in every 2 to 3 deaths, and most of these patients had sepsis at…

Vitamin D Supplementation Does Not Improve Asthma Treatment, Symptoms For Adults With Low Vitamin D Levels

EMBARGOED FOR EARLY RELEASE: 4 P.M. (CT) SUNDAY, MAY 18, 2014 Media Advisory: To contact corresponding author Tonya S. King, Ph.D., call Matthew Solovey at 717-531-0003, ext. 287127, or email msolovey@hmc.psu.edu. In adults with persistent asthma and low vitamin D levels, treatment with vitamin D3 did not reduce the rate of treatment failure or exacerbation…

JAMA:05132014

Large Increase Seen in Emergency Departments Visits for Traumatic Brain Injury

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 13, 2014 Media Advisory: To contact Jennifer R. Marin, M.D., M.Sc., call Anita Srikameswaran at 412-578-9193 or email srikamav@upmc.edu. Between 2006 and 2010, there was a nearly 30 percent increase in the rate of visits to an emergency department for traumatic brain injury, which may be attributable…

Study Findings Question Benefit of Additional Imaging Before Cancer Surgery

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 13, 2014 Media Advisory: To contact corresponding author Mark N. Levine, M.D., call Veronica McGuire at 905-525-9140, ext. 22169; or email vmcguir@mcmaster.ca. Among patients with a certain type of colorectal cancer with limited spread to the liver, imaging using positron emission tomography and computed tomography (CT) before…

Difference Found in Brain Area Linked to Memory Among College Football Players

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 13, 2014 Media Advisory: To contact corresponding author Patrick S.F. Bellgowan, Ph.D., call Hannah Jackson at 918-430-3011 or email hjackson@stfpr.com. Preliminary research finds that within a group of collegiate football players, those who experienced a concussion or had been playing for more years had smaller hippocampal volume…

Study Examines Effectiveness of Medications to Treat Alcohol Use Disorders

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 13, 2014 Media Advisory: To contact Daniel E. Jonas, M.D., M.P.H., call Thania Benios at 919-962-8596 or email thania_benios@unc.edu. To contact editorial co-author Katharine A. Bradley, M.D., M.P.H., call Rebecca Hughes at 206-287-2055 or email hughes.r@ghc.org.   An analysis of more than 120 studies that examined the…

Monoclonal Antibody Combined With Statin Results in Further Reduction of Cholesterol Levels

Media Advisory: To contact Jennifer G. Robinson, M.D., M.P.H., call Jennifer Brown at 319-356-7124 or email jennifer-l-brown@uiowa.edu. Among patients with high cholesterol receiving moderate- or high-intensity statin therapy, the addition of the human monoclonal antibody evolocumab resulted in additional lowering of low-density lipoprotein cholesterol (LDL-C) levels, according to a study in the May 14 issue…

JAMA:05032014

Steroid Therapy Following Surgery Does Not Significantly Improve Outcomes for Infants With Bile Duct Disorder

EMBARGOED FOR EARLY RELEASE: 3 P.M. (CT) SATURDAY, MAY 3, 2014 Media Advisory: To contact Jorge A. Bezerra, M.D., call Nick Miller at 513-803-6035 or email nicholas.miller@cchmc.org. Among infants who underwent surgery to repair bile ducts that do not drain properly (biliary atresia), the administration of high-dose steroid therapy following surgery did not significantly improve…

Medication Does Not Lower Risk of Fungal Infection, Death Among Extremely Low Birth-Weight Infants

EMBARGOED FOR EARLY RELEASE: 3 P.M. (CT) SATURDAY, MAY 3, 2014 Media Advisory: To contact Daniel K. Benjamin Jr., M.D., Ph.D., call Sarah Avery at 919-660-1306 or email sarah.avery@duke.edu. Use of the antifungal medication fluconazole for six weeks for extremely low birth-weight infants did not significantly reduce the risk of death or invasive candidiasis, a…

Receiving Tdap Vaccine During Pregnancy Does Not Appear to Increase Risk of Adverse Events For Mother or Infant

EMBARGOED FOR EARLY RELEASE: 3 P.M. (CT) SATURDAY, MAY 3, 2014 Media Advisory: To contact Flor M. Munoz, M.D., call Dipali Pathak at 713-798-4710 or email pathak@bcm.edu. To contact editorial co-author Kathryn M. Edwards, M.D., call Craig Boerner at 615-322-4747 or email craig.boerner@vanderbilt.edu. A preliminary study finds that receipt of the tetanus toxoid, reduced diphtheria…

Low Rate of Cholesterol Testing For Children and Adolescents

EMBARGOED FOR EARLY RELEASE: 3 P.M. (CT) SATURDAY, MAY 3, 2014 Media Advisory: To contact corresponding author Sarah D. de Ferranti, M.D., M.P.H., call Rob Graham at 617-919-3110 or email Rob.graham@childrens.harvard.edu.   Although some guidelines recommend lipid screening for children and adolescents of certain ages, data indicate that only about 3 percent are having their…

Omega-3 Fatty Acid Supplementation During Pregnancy Does Not Appear to Improve Cognitive Outcomes for Children

EMBARGOED FOR EARLY RELEASE: 3 P.M. (CT) SATURDAY, MAY 3, 2014 Media Advisory: To contact Maria Makrides, B.Sc., B.N.D., Ph.D., email maria.makrides@health.sa.gov.au. Although there are recommendations for pregnant women to increase their intake of the omega-3 fatty acid docosahexaenoic acid (DHA) to improve fetal brain development, a randomized trial finds that prenatal DHA supplementation did…

Findings Suggest That Genetic, Environmental Factors Have Similar Influence on Risk of Autism

EMBARGOED FOR EARLY RELEASE: 3 P.M. (CT) SATURDAY, MAY 3, 2014 Media Advisory: To contact Sven Sandin, M.Sc., email Sven.Sandin@ki.se. To contact editorial co-author Diana E. Schendel, Ph.D., email diana.schendel@folkesundhed.au.dk.   The risk of autism may be influenced equally by genetic and environmental factors; in addition, a sibling of a family member with autism has…