Gastrointestinal Interoception and Relapse in Anorexia Nervosa

Is gastrointestinal interoception abnormal in anorexia nervosa, and do corresponding markers predict relapse and symptom severity at 6 months?In this crossover trial, female participants with anorexia nervosa showed abnormal gastrointestinal interoception at the behavioral and computational level, despite intact neural and physiological responses, compared with healthy participants. Behavioral and computational markers of disrupted gastrointestinal interoception predicted relapse and symptom severity.This study provides evidence that disruptions of gastrointestinal interoception in anorexia nervosa predict relapse and may serve as scalable biomarkers to personalize treatment and prevent recurrence.

Corresponding Author: Sahib S. Khalsa MD, PhD, Semel Institute for Neuroscience and Human Behavior, UCLA Geffen School of Medicine, 300 UCLA Medical Plaza, Los Angeles, CA 90095 (skhalsa@mednet.ucla.edu).

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