Dementia in Severe Schizophrenia

Is the dementia of severe schizophrenia a distinct clinical entity?In this cohort study, 155 individuals with severe, extremely treatment-resistant schizophrenia were characterized. The pattern of cognitive impairments differed from those of Alzheimer disease, frontotemporal dementia, and Lewy body dementia, but recapitulated and intensified that of community-dwelling schizophrenia.This study accords with previous work suggesting that dementia is a common outcome of schizophrenia and may arise from the illness itself.

Corresponding Author: Anthony W. Zoghbi, MD, Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 1 Baylor Plaza, Taub Building, Room T111, Houston, TX 77030 (anthony.zoghbi@bcm.edu).

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