A Ketogenic Diet for Treatment-Resistant Depression

Does a ketogenic diet (KD; high fat, low carbohydrate) vs a control diet improve mental health outcomes in individuals with treatment-resistant depression (TRD)?In this randomized clinical trial of 88 UK participants with TRD, both the KD and control groups reported rapid improvements in depression. After 6 weeks, the improvement was greater in the KD group than in the control group.This randomized clinical trial suggests that KDs may be effective as an adjunctive treatment for TRD.

Corresponding Author: Min Gao, PhD, Nuffield Department of Primary Care Health Sciences, University of Oxford, Woodstock Rd, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Oxford OX2 6GG, England (min.gao@phc.ox.ac.uk).

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