Mental Disorders as a Risk Factor of Acute Coronary Syndrome

What is the association between mental disorders and acute coronary syndrome (ACS)?In this systematic review and meta-analysis including 25 full-text articles with 22 048 504 participants, posttraumatic stress disorder (PTSD) and depressive, anxiety, and sleep disorders were generally associated with increased risk of ACS, with PTSD and sleep disorders underscoring the importance of sleep quality on cardiovascular outcomes. Meanwhile, bipolar and schizophrenia-spectrum disorders were unclearly associated with ACS.Sleep and other mental disorder–driven behaviors may mediate ACS risk in this patient population; future research addressing these limitations could provide more nuanced insights into the association between mental health and ACS.

Corresponding Author: Arnav Gupta, MD, MSc, Department of Medicine, University of Calgary, 9th Floor North Tower, 1403 29 Street NW, Calgary, AB T2N 2T9, Canada (arnav.gupta@albertahealthservices.ca).

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