Special Communication

Artificial Intelligence and the Potential Transformation of Mental Health

JAMA Psychiatry 10.1001/jamapsychiatry.2025.4116

January 14, 2026 at 11:00 AM EST

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The likely benefits of AI for psychiatric care delivery must be balanced against substantial risks. Strategies to mitigate this risk may require regulation to enhance transparency and systematically evaluate the impact of AI in practice, as well as clinician training to make optimal use of these emerging methods.

Corresponding Author: Roy H. Perlis, MD, MSc, Massachusetts General Hospital, 185 Cambridge St, 6th Floor, Boston, MA 02114 (rperlis@mgb.org).

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