Research Letter

Structural Drivers of the Drop in Opioid Overdose Deaths in the US

JAMA Psychiatry 10.1001/jamapsychiatry.2025.3584

November 26, 2025 at 11:00 AM EST

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This decision analytical model uses the SOURCE model to elucidate factors underlying the recent decline in US overdose deaths.

Corresponding Author: Mohammad S. Jalali, PhD, Massachusetts General Hospital, Harvard Medical School, 125 Nashua St, Room 6612, Boston, MA 02114 (msjalali@mgh.harvard.edu).

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