Original Investigation

Parental Mental Disorders and Offspring Mortality up to Middle Age

JAMA Psychiatry 10.1001/jamapsychiatry.2025.2572

September 24, 2025 at 11:00 AM EDT

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Are parental mental disorders associated with an increased risk of mortality in offspring?In this cohort study including 3 548 788 individuals, all major types of parental mental disorders were associated with increased risks of offspring mortality up to the age of 51 years. The associations were strongest for unnatural deaths and when both parents had mental disorders.The findings of this study emphasize the importance of providing support for families with parents with mental disorders; further studies are needed to investigate whether such support may reduce the risk of premature death in affected offspring.

Corresponding Author: Hui Wang, PhD, Department of Global Public Health, Karolinska Institutet, Solnavägen 1E, 113 65 Stockholm, Sweden (hui.wang2@ki.se).

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