Brief Report

Risk Factors for Catatonia Relapse in Psychotic and Affective Disorders

JAMA Psychiatry 10.1001/jamapsychiatry.2025.1818

July 30, 2025 at 11:00 AM EDT

Read the full article

What is the relapse rate of catatonia and what risk factors are associated with relapse in patients with psychotic and affective spectrum disorders?In this cohort study involving 303 patients, nearly 49% of patients experienced a relapse, with the highest risk within 2 years of an index catatonic episode and similar relapse rates across psychotic and affective spectrum disorders. Antipsychotic prescription at discharge was associated with reduced relapse risk.Findings of this study suggest that catatonia is a recurrent condition with frequent early relapse, and while antipsychotics potentially play a role in relapse prevention, further research is needed to facilitate the development of structured relapse prevention strategies.

Corresponding Author: Venkata Senthil Kumar Reddi, MD, Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Hosur Road, Bengaluru, India 560029 (sreddi@nimhans.ac.in).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2025.1818?utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_term=073025

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.

Editor's Picks