Risk Factors for Catatonia Relapse in Psychotic and Affective Disorders
JAMA Psychiatry 10.1001/jamapsychiatry.2025.1818July 30, 2025 at 11:00 AM EDT
What is the relapse rate of catatonia and what risk factors are associated with relapse in patients with psychotic and affective spectrum disorders?In this cohort study involving 303 patients, nearly 49% of patients experienced a relapse, with the highest risk within 2 years of an index catatonic episode and similar relapse rates across psychotic and affective spectrum disorders. Antipsychotic prescription at discharge was associated with reduced relapse risk.Findings of this study suggest that catatonia is a recurrent condition with frequent early relapse, and while antipsychotics potentially play a role in relapse prevention, further research is needed to facilitate the development of structured relapse prevention strategies.
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