Late Outcomes Following Acute Kidney Injury in Children

What are the late adverse consequences among survivors of pediatric acute kidney injury (AKI)?In this systematic review and meta-analysis of 39 studies involving 16 151 children, AKI was associated with an increased risk of late adverse outcomes. Children with a history of AKI had higher odds of developing chronic kidney disease and higher late mortality, and risk was further elevated in those with more severe AKI.These findings underscore the importance of structured, long-term follow-up and kidney health surveillance for children after AKI, particularly for those with moderate or severe injury.

Corresponding Author: Rahul Chanchlani, MD, MSc, Division of Pediatric Nephrology, Department of Pediatrics, McMaster Children’s Hospital, McMaster University, 1280 Main St W, Hamilton, ON L8N 3Z5, Canada (chanchlr@mcmaster.ca).

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