Cerebral Oximetry in Extremely Preterm Infants

Does treatment guided by cerebral oximetry monitoring during the first 72 hours after birth reduce the risk of death or moderate or severe neurodevelopmental disability and cognitive impairment at 2 years of corrected age in extremely preterm infants?In this 2-year follow-up of the Safeguarding the Brain of Our Smallest Children (SafeBoosC-III) randomized clinical trial including 1438 infants, death or moderate or severe neurodevelopmental disability did not differ between the cerebral oximetry group and the usual-care group, and mean Bayley cognitive scores at 2 years did not differ significantly between groups.Results reveal that the routine use of cerebral oximetry monitoring during the first 72 hours after birth in extremely preterm infants to reduce death or moderate or severe neurodevelopmental disability and cognitive impairment was not supported by this trial.

Corresponding Author: Marie Isabel Skov Rasmussen, MD, PhD, Department of Pediatric and Neonatal Intensive Care, Copenhagen University Hospital–Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark (marie.isabel.skov.rasmussen@regionh.dk).

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