Viewpoint

Preventing Excess Fat Mass Gain in Severe Pediatric Obesity

JAMA Pediatrics 10.1001/jamapediatrics.2025.5145

December 29, 2025 at 11:00 AM EST

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This Viewpoint presents a theoretical model to illustrate how treatment with antiobesity medications could reshape body mass index and fat-mass trajectories in children and adolescents.

Corresponding Author: Martin Wabitsch, Dr med, Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Eythstrasse 24, 89075 Ulm, Germany (martin.wabitsch@uniklinik-ulm.de).

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