Review

Suicide Interventions for Youths

JAMA Pediatrics 10.1001/jamapediatrics.2025.3485

September 29, 2025 at 11:00 AM EDT

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This systematic review found that the current evidence on available interventions targeting youths at heightened risk of suicide is uncertain. Medication, neurotherapeutics, and emerging therapies remain unstudied among this population. The limited evidence base calls for the development of novel, developmentally and trauma-informed treatments, as well as multilevel interventions to target the increasing suicide risk among youths.

Corresponding Author: M. Hassan Murad, MD, MPH, Mayo Clinic Evidence-Based Practice Center, Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Healthcare Delivery, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (murad.mohammad@mayo.edu).

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