Routine vs Selective Calcium Supplementation After Total Thyroidectomy
JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2025.5514February 19, 2026 at 11:00 AM EST
Is selective calcium and calcitriol (C+C) supplementation, guided by postoperative PTH levels, a better strategy than routine supplementation for preventing symptomatic hypocalcemia after total thyroidectomy?In this randomized clinical trial of 258 patients, the incidence of symptomatic hypocalcemia in the selective C+C supplementation group (7.8%) compared with the routine C+C supplementation group (11.1%) was not signicantly different.Selective C+C supplementation based on postoperative PTH levels is not superior to routine supplementation; both are viable options that can be used according to available resources and clinical context.
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